Now showing items 1-5 of 5

    • The dilemma of diagnosing coenzyme Q10 deficiency in muscle 

      Louw, Roan; Wilsenach, Kimmey-Li; Jonck, Lindi-Maryn; Schoonen, Maryke; Van der Westhuizen, Francois H. (Elsevier, 2018)
      Background Coenzyme Q10 (CoQ10) is an important component of the mitochondrial respiratory chain (RC) and is critical for energy production. Although the prevalence of CoQ10 deficiency is still unknown, the general consensus ...
    • A metabolomics and biochemical investigation of selected brain regions from Ndufs4 knockout mice 

      Coetzer, J. (North-West University (South Africa)North-West University, 2020)
      Mitochondria, the organelles found throughout the cytoplasm of most eukaryotic cells, have essential functions which have been implicated in the etiology of numerous metabolic and degenerative diseases. The mitochondrial ...
    • Metabolomics of mitochondrial disease 

      Esterhuizen, Karien; Van der Westhuizen, Francois H.; Louw, Roan (Elsevier, 2017)
      Mitochondrial disease (MD) diagnostics and disease progression investigations have traditionally relied very little on metabolic data, due to a lack of biomarker sensitivity and specificity. The recent drive to find novel, ...
    • Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types 

      Tomas, Cara; Elson, Joanna L.; Brown, Audrey E.; Newton, Julia L. (Tomas, 2019)
      Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on ...
    • OXPHOS gene expression and control in mitochondrial disorders 

      Reinecke, Fimmie; Van der Westhuizen, Francois H.; Smeitink, Jan A.M. (Elsevier, 2009)
      The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca2+, ADP/ATP, and NAD/NADH. The adaptive responses to ...