Browsing by Subject "Obsessive-compulsive disorder"
Now showing items 1-10 of 19
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Cognitive flexibility in the deer mouse and its response to escitalopram and levetiracetam
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 causes functional impairment which severely and negatively impacts the lives of affected individuals. As its name suggests, OCD is characterised by both obsessions and compulsions. The ... -
Cognitive flexibility in the deer mouse model of obsessive-compulsive disorder and its response to serotonin and adenosine modulation
(North-West University (South-Africa), 2021)Obsessive-compulsive disorder (OCD)1 is a phenotypically heterogeneous psychiatric disorder characterised by repetitive and ritualised behaviours (compulsions), that are purportedly enacted to attenuate the level of distress ... -
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
(Elsevier, 2011)The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ... -
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward
(Springer, 2019)Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds ... -
Dopaminergic and serotonergic modulation of reward appraisal in the zebrafish (Danio rerio)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD)1 is a chronic and debilitating neuropsychiatric condition affecting 1 – 3% of the world population. The condition is characterized by two main symptom cohorts namely recurrent, distressing ... -
Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action
(Elsevier, 2020)Cognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test ... -
Ethological foundations of measuring obsessive-compulsive phenotypes in the deer mouse: a methodological perspective
(North-West University (South-Africa), 2020)Pre-clinical models which leverage the study of animal behavior are invaluable tools to advance our understanding of a variety of psychological constructs. Such ethological investigations allow us to gain insight into ... -
An investigation into the potential neurobiological constructs and long-term biobehavioural effects of perinatal combined antiretroviral therapy (cART)-exposure in the deer mouse
(North-West University (South-Africa), 2022)South Africa has one of the largest combination antiretroviral treatment (cART1) programs in the world with an estimated 7.52 million individuals that were living with human immunodeficiency virus (HIV2) by the end of 2018. ... -
Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models
(Elsevier, 2012)Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and have severe health and socio-economic implications. Despite the availability of a number of treatment options there is still a strong ... -
A metagenomic microbiome investigation in the deer mouse : a translational approach to obsessive-compulsive disorder
(North-West University (South-Africa), 2019)Obsessive-compulsive disorder (OCD)1 is characterized by persistent, intrusive and often anxiety-provoking thoughts, i.e. obsessions and/or ritualistic behaviors (compulsions) that are expressed in an attempt to reduce the ...