Browsing by Subject "Striatum"
Now showing items 1-8 of 8
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Behavioral, neuroendocrine and neurochemical studies on agomelatine in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)1. Introduction. There is currently a large body of evidence suggesting that stressful early life experiences, such as maternal separation and social isolation, may play a role in the development of major depressive disorder ... -
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
(Elsevier, 2009)Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ... -
An investigation into the effects of Sceletium tortuosum in a methamphetamine addiction model in Sprague Dawley rats
(North-West University (South-Africa), 2021)Background: Methamphetamine (MA), globally known as “crystal meth”, is a highly addictive psychostimulant, which can be easily synthesized by using over the counter medicine and common household items. It induces intense ... -
Late-life effects of chronic methamphetamine exposure during puberty on behaviour and corticostriatal mono-amines in social isolation-reared rats
(Karger, 2014)Chronic methamphetamine (MA) abuse results in an acute psychosis indistinguishable from paranoid schizophrenia. However, less is known of the interaction between MA use and environmental insults, and how this contributes ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
Obsessive-compulsive disorder: insights from animal models
(Elsevier, 2016)Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ... -
The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time
(Springer, 2011)Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ...