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dc.contributor.authorAsayama, K.E.I.
dc.contributor.authorJacobs, Lotte
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorStaessen, Jan
dc.contributor.authorGu, Yu-Mei
dc.contributor.authorJin, Yu
dc.date.accessioned2014-02-06T13:53:08Z
dc.date.available2014-02-06T13:53:08Z
dc.date.issued2012
dc.identifier.citationSchutte, Rudolph et al. 2012. Within-subject blood pressure level – not variability – predicts fatal and nonfatal outcomes in a general population. Hypertension, 60(5):1138-1147. [http://hyper.ahajournals.org/]en_US
dc.identifier.issn0194-911X
dc.identifier.issn1524-4563
dc.identifier.urihttp://hdl.handle.net/10394/10072
dc.identifier.urihttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.202143
dc.description.abstractTo assess the prognostic significance of blood pressure (BP) variability, we followed health outcomes in a family-based random population sample representative of the general population (n=2944; mean age: 44.9 years; 50.7% women). At baseline, BP was measured 5 times consecutively at each of 2 home visits 2 to 4 weeks apart. We assessed within-subject overall (10 readings), within- and between-visit systolic BP variability from variability independent of the mean, the difference between maximum and minimum BP, and average real variability. Over a median follow-up of 12 years, 401 deaths occurred and 311 participants experienced a fatal or nonfatal cardiovascular event. Overall systolic BP variability averaged (SD) 5.45 (2.82) units, 15.87 (8.36) mmHg, and 4.08 (2.05) mmHg for variability independent of the mean, difference between maximum and minimum BP, and average real variability, respectively. Female sex, older age, higher-mean systolic BP, lower body mass index, a history of peripheral arterial disease, and use of β-blockers were the main correlates of systolic BP variability. In multivariable-adjusted analyses, overall and within- and between-visit BP variability did not predict total or cardiovascular mortality or the composite of any fatal plus nonfatal cardiovascular end point. For instance, the hazard ratios for all cardiovascular events combined in relation to overall variability independent of the mean, difference between maximum and minimum BP, and average real variability were 1.05 (0.96–1.15), 1.06 (0.96–1.16), and 1.08 (0.98–1.19), respectively. By contrast, mean systolic BP was a significant predictor of all end points under study, independent of BP variability. In conclusion, in an unbiased population sample, BP variability did not contribute to risk stratification over and beyond mean systolic BP.en_US
dc.language.isoenen_US
dc.publisherAmerican Heart Associationen_US
dc.subjectBlood pressure variabilityen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectpopulation scienceen_US
dc.subjectrisk factorsen_US
dc.subjectepidemiologyen_US
dc.titleWithin-subject blood pressure level – not variability – predicts fatal and nonfatal outcomes in a general populationen_US
dc.typeArticleen_US
dc.contributor.researchID12201405 - Schutte, Rudolph


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