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dc.contributor.authorMels, Catharina Martha Cornelia
dc.contributor.authorPieterse, Chiné
dc.contributor.authorSchutte, Aletta Elisabeth
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorSmith, Wayne
dc.date.accessioned2014-02-07T09:30:27Z
dc.date.available2014-02-07T09:30:27Z
dc.date.issued2012
dc.identifier.citationPieterse, C. et al. 2012. Carotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA study. Hypertension research, 35(12):1185-1192. [http://www.nature.com/hr/index.html]en_US
dc.identifier.issn0916-9626
dc.identifier.issn1348-4214
dc.identifier.urihttp://hdl.handle.net/10394/10073
dc.identifier.urihttp://dx.doi.org/10.1038/hr.2012.130
dc.identifier.urihttp://www.nature.com/hr/journal/v35/n12/pdf/hr2012130a.pdf
dc.description.abstractHypertension and obesity are serious health burdens in sub-Saharan Africa. Urbanized Africans seem to be more susceptible to the development of these diseases than Caucasians. Current research suggests that leptin may be an important contributor to the development of hypertension and atherosclerosis. The aim of this study was to investigate leptin levels and their associations with cardiovascular function in urbanized Africans and Caucasians. Serum leptin, ambulatory blood pressure and carotid intima-media thickness were measured, and the cross-sectional wall area (CSWA) was calculated. The results showed that Africans had higher leptin levels (Po0.001), ambulatory blood pressure (Po0.001), carotid intima-media thickness (Po0.01) and CSWA (Po0.01) than Caucasians. As we found no interaction between ethnicity and gender for the association between leptin and the cardiovascular variables, we focused mainly on the total group of Africans and Caucasians. In single, partial and multiple regression analyses, positive associations of ambulatory systolic blood pressure (b¼0.256; Po0.001), diastolic blood pressure (b¼0.143; P¼0.012), pulse pressure (b¼0.327; Po0.001) and CSWA (b¼0.107; P¼0.038) with leptin were observed. Even after adjusting for body mass index (BMI), the association between CSWA (b¼0.107; P¼0.038) and leptin remained. Our findings therefore suggest that leptin may contribute to the development of atherosclerosis, independent of BMI.en_US
dc.language.isoenen_US
dc.publisherJapanese Society of Hypertensionen_US
dc.publisherNature Publishing Group
dc.subjectAtherosclerosisen_US
dc.subjectblood pressureen_US
dc.subjectcross-sectional wall areaen_US
dc.subjectethnicityen_US
dc.subjectleptinen_US
dc.titleCarotid cross-sectional wall area is significantly associated with serum leptin levels, independent of body mass index: the SABPA studyent of body mass index: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID12076341 - Mels, Catharina Martha Cornelia
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID20684444 - Pieterse, Chiné
dc.contributor.researchID22945717 - Smith, Wayne


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