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dc.contributor.authorHamlyn, Eugene
dc.contributor.authorBrand, Linda
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorShadid, Mohammed
dc.contributor.authorHamlyn, Eugene
dc.contributor.authorBrand, Linda
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorShadid, Mohammed
dc.date.accessioned2014-08-12T06:49:40Z
dc.date.available2014-08-12T06:49:40Z
dc.date.issued2009
dc.identifier.citationHamlyn, E. et al. 2009. The ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in rats. Behavioural pharmacology, 20(7):662-667. [http://dx.doi.org/10.1097/FBP.0b013e328331ba1b]en_US
dc.identifier.issn0955-8810
dc.identifier.issn1473-5849
dc.identifier.urihttp://hdl.handle.net/10394/11063
dc.identifier.urihttps://doi.org/10.1097/FBP.0b013e328331ba1b
dc.identifier.urihttps://journals.lww.com/behaviouralpharm/Abstract/2009/10000/The_ampakine,_Org_26576,_bolsters_early_spatial.14.aspx
dc.description.abstractAmpakines have shown beneficial effects on cognition in selected animal models of learning. However, their ability to modify long-term spatial memory tasks has not been studied yet. This would lend credence to their possible value in treating disorders of cognition. We evaluated the actions of subchronic Org 26576 administration on spatial reference memory performance in the 5-day Morris water maze task in male Sprague–Dawley rats, at doses of 1, 3 and 10 mg/kg twice daily through intraperitoneal injection over 12 days. Org 26576 exerted a dose and time-dependent effect on spatial learning, with dosages of 3 and 10 mg/kg significantly enhancing acquisition on day 1. Globally, escape latency decreased significantly as the training days progressed in the saline and Org 26576-treated groups, indicating that significant and equal learning had taken place over the learning period. However, at the end of the learning period, all doses of Org 26576 significantly improved spatial memory storage/ retrieval without confounding effects in the cued version of the task. Org 26576 offers early phase spatial memory benefits in rats, but particularly enhances search accuracy during reference memory retrieval. These results support its possible utility in treating disorders characterized by deficits in cognitive performance.en_US
dc.language.isoenen_US
dc.publisherWolters Kluweren_US
dc.subjectAmpakineen_US
dc.subjectAMPA receptoren_US
dc.subjectCognitionen_US
dc.subjectLearningen_US
dc.subjectMorris water mazeen_US
dc.subjectOrg 26576en_US
dc.subjectRaten_US
dc.subjectSpatial reference memoryen_US
dc.titleThe ampakine, Org 26576, bolsters early spatial reference learning and retrieval in the Morris water maze: a subchronic, dose-ranging study in ratsen_US
dc.typeArticleen_US
dc.contributor.researchID10066357 - Brand, Linda
dc.contributor.researchID11083417 - Harvey, Brian Herbert


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