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dc.contributor.authorBuys, Gerhard M.
dc.contributor.authorDu Plessis, Lissinda H.
dc.contributor.authorMarais, Andries F.
dc.contributor.authorKotzé, Awie F.
dc.contributor.authorHamman, Josias H.
dc.identifier.citationBuys, G.M. et al. 2013. Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance. Current drug delivery, 10(3):348-356. []en_US
dc.identifier.issn1875-5704 (Online)
dc.description.abstractChitosan is a polymer derived from chitin that is widely available at relatively low cost, but due to compression challenges it has limited application for the production of direct compression tablets. The aim of this study was to use certain process and formulation variables to improve manufacturing of tablets containing chitosan as bulking agent. Chitosan particle size and flow properties were determined, which included bulk density, tapped density, compressibility and moisture uptake. The effect of process variables (i.e. compression force, punch depth, percentage compaction in a novel double fill compression process) and formulation variables (i.e. type of glidant, citric acid, pectin, coating with Eudragit S®) on chitosan tablet performance (i.e. mass variation, tensile strength, dissolution) was investigated. Moisture content of the chitosan powder, particle size and the inclusion of glidants had a pronounced effect on its flow ability. Varying the percentage compaction during the first cycle of a double fill compression process produced chitosan tablets with more acceptable tensile strength and dissolution rate properties. The inclusion of citric acid and pectin into the formulation significantly decreased the dissolution rate of isoniazid from the tablets due to gel formation. Direct compression of chitosan powder into tablets can be significantly improved by the investigated process and formulation variables as well as applying a double fill compression process.en_US
dc.publisherBentham Science
dc.subjectComposite indexen_US
dc.subjectPowder flowen_US
dc.subjectTensile strengthen_US
dc.titleDirect compression of chitosan: process and formulation factors to improve powder flow and tablet performanceen_US
dc.contributor.researchID11948388 - Du Plessis, Lissinda Hester
dc.contributor.researchID10062688 - Marais, Andries Francois
dc.contributor.researchID10200142 - Kotzé, Abraham Frederik
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID10063692 - Buys, Gerhardus Martinus

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