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dc.contributor.authorBadenhorst, Christoffel Petrus Stephanus
dc.contributor.authorErasmus, Elardus
dc.contributor.authorVan der Sluis, Rencia
dc.contributor.authorVan Dijk, Alberdina Aike
dc.identifier.citationBadenhorst, C.P.S. et al. 2013. Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation. Expert opinion on drug metabolism & toxicology, 9(9):1139-1153. []en_US
dc.identifier.issn1744-7607 (Online)
dc.description.abstractIntroduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C., is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A (CoASH). However, because of the small number of pharmaceutical drugs that are conjugated to glycine, the pathway has not yet been characterized in detail. Here, we review the causes and possible consequences of interindividual variation in the glycine conjugation pathway. Areas covered: The authors review the importance of CoASH in metabolism, formation and toxicity of xenobiotic acyl-CoAs, and mechanisms for restoring levels of CoASH. They focus on GLYAT, glycine conjugation, how genetic variation in the GLYAT gene could influence glycine conjugation, and the emerging roles of glycine metabolism in cancer and musculoskeletal development. Expert opinion: The substrate selectivity of GLYAT and its variants needs to be further characterized, as organic acids can be toxic if the corresponding acyl-CoA is not a substrate for glycine conjugation. GLYAT activity affects mitochondrial ATP production, glycine availability, CoASH availability, and the toxicity of various organic acids. Therefore, variation in the glycine conjugation pathway could influence liver cancer, musculoskeletal development, and mitochondrial energy metabolism. Read More:
dc.publisherTaylor & Francisen_US
dc.subjectAcyl-coenzyme Aen_US
dc.subjectCASTOR disorderen_US
dc.subjectCoenzyme Aen_US
dc.subjectCoenzyme A sequestrationen_US
dc.subjectGlycine conjugationen_US
dc.subjectGlycine N-acyltransferaseen_US
dc.subjectHepatocellular carcinomaen_US
dc.titleGlycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variationen_US
dc.contributor.researchID10066136 - Erasmus, Elardus
dc.contributor.researchID21224919 - Van der Sluis, Rencia
dc.contributor.researchID10997938 - Van Dijk, Alberdina Aike
dc.contributor.researchID21489459 - Badenhorst, Christoffel Petrus Stephanus

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