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dc.contributor.authorDwivedi, Anupma
dc.contributor.authorMazumder, Anisha
dc.contributor.authorDu Plessis, Lissinda
dc.contributor.authorDu Preez, Jan L.
dc.contributor.authorHaynes, Richard K.
dc.contributor.authorDu Plessis, Jeanetta
dc.date.accessioned2015-10-15T14:11:18Z
dc.date.available2015-10-15T14:11:18Z
dc.date.issued2015
dc.identifier.citationDwivedi A. et al. 2015. In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells. Nanomedicine: nanotechnology, biology and medicine, 11(8):2041-2050. [https://doi.org/10.1016/j.nano.2015.07.010]en_US
dc.identifier.issn1549-9634
dc.identifier.issn1549-9642 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/14769
dc.identifier.urihttps://doi.org/10.1016/j.nano.2015.07.010
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1549963415001537
dc.description.abstractArtemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalise on the last property, we have examined the encapsulation of artemisone in nano-vesicular niosomes and solid lipid nanoparticles (SLNs), and have evaluated efficacies of the free and encapsulated artemisone against human melanoma A-375 cells and effects on human keratinocytes (HaCaT). Artemisone is successfully encapsulated into the nano-vesicles with encapsulation efficiencies of 67 ± 6% and 79 ± 5%, and with average particle sizes being 211 ± 10 nm and 295 ± 18 nm respectively. The formulations displayed highly selective cytotoxicity towards the melanoma cells with negligible toxicity towards the normal skin cells. The artemisone-loaded nano-vesicles almost completely inhibited the melanoma cells compared to the free drug. The results overall suggest a potentially more useful therapeutic strategy that needs to be evaluated for the treatment of melanoma and other cancers.en_US
dc.description.sponsorshipNational Research Foundation of South Africa (NRF)en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectArtemisoneen_US
dc.subjectNano-vesiclesen_US
dc.subjectNiosomesen_US
dc.subjectSolid lipid nanoparticles (SLN)en_US
dc.subjectCytotoxicen_US
dc.subjectMelanomaen_US
dc.titleIn vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cellsen_US
dc.typeArticleen_US
dc.contributor.researchID10065318 - Du Plessis, Jeanetta
dc.contributor.researchID25224735 - Dwivedi, Anupma
dc.contributor.researchID25224786 - Mazumder, Anisha
dc.contributor.researchID10060510 - Du Preez, Jan Lourens
dc.contributor.researchID22966390 - Haynes, Richard Kingston
dc.contributor.researchID11948388 - Du Plessis, Lissinda Hester


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