dc.contributor.author | Pieterse, Chiné | |
dc.contributor.author | Schutte, Ramoteme, L. | |
dc.contributor.author | Schutte, Aletta E. | |
dc.date.accessioned | 2016-01-18T06:01:29Z | |
dc.date.available | 2016-01-18T06:01:29Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Pieterse, C. et al. 2014. Autonomic activity and leptin in Africans and whites: the SABPA study. Journal of hypertension, 32(4):826-833. [http://resolver.ebscohost.com.nwulib.nwu.ac.za/openurl/?sid=google&id=pmid%3a24509121&linksourcecustid=643] | en_US |
dc.identifier.issn | 0041-4751 | |
dc.identifier.uri | http://hdl.handle.net/10394/15877 | |
dc.identifier.uri | http://resolver.ebscohost.com.nwulib.nwu.ac.za/openurl/?sid=google&id=pmid%3a24509121&linksourcecustid=643 | |
dc.description.abstract | Objectives: Evidence exists that leptin enhances sympathetic activity and may thereby contribute to the development of obesity-related hypertension. Sympathetic activation also seems more prominent in Africans than whites. We compared leptin levels, and different markers of autonomic activity between Africans and whites, and determined whether a relationship exists between leptin and autonomic activity.
Methods: The study included 409 African and white school teachers (aged, 44.6 ± 9.6 years). We determined leptin in serum and measured ambulatory blood pressure. Markers reflecting autonomic activity included renin, cortisol, baroreflex sensitivity, ambulatory heart rate and heart rate variability (HRV) components (assessed by 24-h ECG recordings in the frequency and geometric domain).
Results: Africans had higher leptin levels, BMI, blood pressure and heart rate (all P < 0.001) as well as lower HRV triangular index and HRV total power (P < 0.001). After also adjusting for BMI in multivariate regression analyses, in African men, renin ([beta] = 0.228; P = 0.033), night-time heart rate ([beta] = 0.184; P = 0.034), HRV triangular index ([beta] = -0.230; P = 0.010) and HRV total power ([beta] = -0.214; P = 0.046) associated with leptin. In white men, leptin associated with 24-h heart rate ([beta] = 0.376; P < 0.001), as well as day and night-time heart rate (both P < 0.01), HRV triangular index ([beta] = -0.335; P < 0.001) and HRV total power ([beta] = -0.403; P < 0.001). In African women, we observed an association of leptin with the total power component of HRV ([beta] = -0.221; P = 0.015) and a borderline association with renin ([beta] = 0.219; P = 0.057). No significant associations were apparent in the white women.
Conclusion: We found that leptin is independently associated with different markers of autonomic activity, especially in men. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer/Lippincott, Williams & Wilkins | en_US |
dc.subject | autonomic nervous system | en_US |
dc.subject | ethnicity and leptin | en_US |
dc.subject | hypertension | en_US |
dc.subject | sympathetic activity | en_US |
dc.title | Autonomic activity and leptin in Africans and whites: the SABPA study | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |