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dc.contributor.authorWallis, Lonette
dc.contributor.authorKleynhans, Elmarie
dc.contributor.authorDu Toit, Trizel
dc.contributor.authorGouws, Chrisna
dc.contributor.authorSteyn, Dewald
dc.contributor.authorSteenekamp, Jan
dc.contributor.authorViljoen, Joe
dc.contributor.authorHamman, Josias
dc.identifier.citationWallis, L. et al. 2014. Novel non-invasive protein and peptide drug delivery approaches. Protein & peptide letters, 21(11):1087-1101. []en_US
dc.identifier.issn1875-5305 (Online)
dc.description.abstractProtein and peptide based therapeutics are typically administered by injection due to their poor uptake when administered via enteral routes of drug administration. Unfortunately, chronic administration of these drugs through multiple injections presents certain patient related problems and it is difficult to mimic the normal physiological release patterns via this mode of drug administration. A need therefore exists to non-invasively deliver these drugs by means of alternative ways such as via the oral, pulmonary, nasal, transdermal and buccal administration routes. Although some attempts of needle free peptide and protein drug delivery have progressed to the clinical stage, relatively limited success has been achieved in terms of commercially available products. Despite the low frequency of clinical breakthroughs with noninvasive protein drug delivery this far, it remains an active research area with renewed interest not only due to its improved therapeutic potential, but also due to the attractive commercial outcomes it offers. It is the aim of this review article to reflect on the main strategies investigated to overcome the barriers against effective systemic protein drug delivery in different routes of drug administration. Approaches based on chemical modifications and pharmaceutical technologies are discussed with reference to examples of drugs and devices that have shown potential, while attempts that have failed are also briefly outlineden_US
dc.publisherBentham Scienceen_US
dc.subjectAbsorption enhancersen_US
dc.subjectEnzymatic and physical barriersen_US
dc.titleNovel non-invasive protein and peptide drug delivery approachesen_US
dc.contributor.researchID20096062 - Wallis, Lonette
dc.contributor.researchID20682115 - Kleynhans, Elmarie
dc.contributor.researchID21649987 - Du Toit, Trizel
dc.contributor.researchID12450960 - Gouws, Chrisna
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID11320036 - Viljoen, Johanna Magdalena
dc.contributor.researchID12297305 - Steyn, Johan Dewald
dc.contributor.researchID10096078 - Steenekamp, Jan Harm

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