Show simple item record

dc.contributor.authorVan Rooyen, Johannes, M.
dc.contributor.authorSchutte, Aletta, E.
dc.contributor.authorHuisman, Hugo, W.
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorFourie, Carla M.T.
dc.contributor.authorMalan, Nicolaas T.
dc.contributor.authorMalan, Leoné
dc.date.accessioned2016-03-29T08:15:54Z
dc.date.available2016-03-29T08:15:54Z
dc.date.issued2014
dc.identifier.citationVan Rooyen, J.M. et al. 2014. End-organ damage in urbanized Africans with low plasma renin levels: the SABPA study. Clinical and experimental hypertension, 36(1):70-75. [http://www.tandfonline.com/doi/pdf/10.3109/10641963.2013.789044]en_US
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/16739
dc.identifier.urihttp://www.tandfonline.com/doi/pdf/10.3109/10641963.2013.789044
dc.identifier.urihttp://dx.doi.org/10.3109/10641963.2013.789044
dc.description.abstractThe purpose of this study was to evaluate whether active renin concentration is associated with markers of end-organ damage in urbanized Africans. This study forms part of the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. For this study, 81 men and 74 women were divided into low- and high-renin groups. Ambulatory blood pressure measurements were conducted. A resting 12-lead ECG was determined in order to determine the gender-specific Cornell voltage. Cardiovascular variables were continuously recorded with the Finometer. Carotid-dorsalis pedis pulse wave velocity was obtained with the Complior acquisition system. The carotid intima-media thickness (CIMT) was obtained with the SonoSite MicroMaxx. Blood samples were collected; serum and plasma were stored at −80 °C for analysis. Anthropometric measurements were taken using standard methods. A general health questionnaire was also completed. The urinary creatinine was determined with a calorimetric method and albumin with a turbidimetric method. The serum sodium and potassium were determined by making use of the Konelab TM 20i Sequential Multiple Analyzer Computer (SMAC). The concentration of active renin in the plasma was analyzed by making use of a high-sensitivity radio-immunometric assay. A negative association (r = −0.29, p < 0.01) exists between renal function (ACR) and plasma renin in the low-renin group (<6.18 pg/mL), which was not observed in Africans with high-renin levels. It seems evident that low renin in black South Africans may result in sub-clinical renal damage and impaired vascular function in a group of urbanized black South Africansen_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectAfricansen_US
dc.subjectend-organ damageen_US
dc.subjectkidneyen_US
dc.subjectreninen_US
dc.subjecturbanizeden_US
dc.titleEnd-organ damage in urbanized Africans with low plasma renin levels: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record