dc.contributor.author | Venter, Telanie | |
dc.contributor.author | Fox, Lizelle Trifena | |
dc.contributor.author | Gerber, Minja | |
dc.contributor.author | Du Preez, Jan L. | |
dc.contributor.author | Van Zyl, Sterna | |
dc.contributor.author | Boneschans, Banie | |
dc.contributor.author | Du Plessis, Jeanetta | |
dc.date.accessioned | 2016-03-30T12:35:54Z | |
dc.date.available | 2016-03-30T12:35:54Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Venter, T. et al. 2016. Physical stability and clinical efficacy of Crocodylus niloticus oil lotion. Revista Brasileira de farmacognosia/Brazilian journal of pharmacognosy, 26(4):521-529. [https://doi.org/10.1016/j.bjp.2016.03.011] | en_US |
dc.identifier.issn | 0102-695X | |
dc.identifier.issn | 1981-528X (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/16741 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0102695X16300497 | |
dc.identifier.uri | https://doi.org/10.1016/j.bjp.2016.03.011 | |
dc.description.abstract | The stability and the anti-ageing, skin hydrating and anti-erythema effects of a commercialized Crocodylus niloticus oil lotion was determined. The lotion was stored at controlled conditions over six months during which several stability tests were performed. For the clinical efficacy studies lotion was applied on volar forearm skin (female volunteers) and compared to a liquid paraffin-containing reference product. Skin hydrating and anti-ageing effects were determined with a Corneometer®, Cutometer® and Visioscan®, following single (three hours) and multiple applications (twelve weeks). The Vapometer® and Mexameter® were utilized to determine this lotion’s anti-erythema effects on sodium lauryl sulfate irritated skin. The lotion demonstrated good stability over 6 months. The reference product increased skin hydration and decreased skin wrinkles to a larger extent than the C. niloticus lotion after a single application, whereas the C. niloticus lotion decreased skin scaliness better than the reference product. During the long-term study, the reference product overall increased skin hydration more than the C. niloticus lotion, whereas C. niloticus lotion increased skin elasticity to a larger extent than the reference product. C. niloticus lotion increased skin wrinkles and decreased skin scaliness over 12 weeks. Compared to non-treated, irritated skin, C. niloticus lotion demonstrated some potential anti-inflammatory characteristics | en_US |
dc.description.sponsorship | National Research Foundation (NRF) of South Africa (Grants no. IFRR81178 and CPRR13091742482) and the Centre of Excellence for Pharmaceutical Sciences (Pharmacen) at the North-West University, Potchefstroom Campus, South Africa | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Formulation | en_US |
dc.subject | stability | en_US |
dc.subject | Crocodylus niloticus oil | en_US |
dc.subject | Lotion | en_US |
dc.subject | Anti-ageing | en_US |
dc.subject | Skin hydration | en_US |
dc.title | Physical stability and clinical efficacy of Crocodylus niloticus oil lotion | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 11329025 - Gerber, Minja | |
dc.contributor.researchID | 10060510 - Du Preez, Jan Lourens | |
dc.contributor.researchID | 10059490 - Boneschans, Barend | |
dc.contributor.researchID | 10065318 - Du Plessis, Jeanetta | |
dc.contributor.researchID | 12815268 - Fox, Lizelle Trifena | |
dc.contributor.researchID | 12942286 - Van Zyl, Esthernia | |
dc.contributor.researchID | 12977829 - Venter, Telanie | |