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    In vitro skin permeation of sinigrin from its phytosome complex

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    Date
    2016
    Author
    Mazumder, Anisha
    Dwivedi, Anupma
    Fox, Lizelle T.
    Brümmer, Alicia
    Du Preez, Jan L.
    Gerber, Minja
    Du Plessis, Jeanetta
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    Abstract
    Objectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The aim of this study was to demonstrate sinigrin drug release from its phytosome complex and also to determine if the phytosome complex enhances the delivery of sinigrin into the skin when compared to free sinigrin. Methods: In vitro Franz cell diffusion studies were performed on human abdominal skin. The morphology of the phytosome complex was examined by transmission electron microscopy. The in vitro drug release was determined by using dialysis sacks. Key findings: The in vitro drug release indicated a controlled and sustained release of sinigrin from the phytosome complex. Tape stripping results showed that the sinigrin-phytosome complex (0.5155 µg/ml) statistically significantly enhanced the delivery of sinigrin into the stratum corneum-epidermis when compared to the free sinigrin (0.0730 µg/ml). Conclusions: These results suggested the possibility of utilizing sinigrin-phytosome complex, to optimally deliver sinigrin to the skin which can be further used for various skin related diseases including wound healing
    URI
    http://hdl.handle.net/10394/17629
    https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.12594
    https://doi.org/10.1111/jphp.12594
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