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dc.contributor.authorStrydom, Schalk J.
dc.contributor.authorOtto, Daniel P.
dc.contributor.authorLiebenberg, Wilna
dc.contributor.authorRose, Warren E.
dc.contributor.authorDe Villiers, Melgardt M.
dc.date.accessioned2016-06-08T09:59:37Z
dc.date.available2016-06-08T09:59:37Z
dc.date.issued2013
dc.identifier.citationStrydom, S.J. et al. 2013. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine: nanotechnology, biology and medicine, 9(1):85-93. [https://doi.org/10.1016/j.nano.2012.03.006]en_US
dc.identifier.issn1549-9634
dc.identifier.urihttp://hdl.handle.net/10394/17677
dc.identifier.urihttps://doi.org/10.1016/j.nano.2012.03.006
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1549963412001700
dc.description.abstractSilver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine) (PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up approach to synthesize highly-soluble AgSD nanoparticles (NPs). These NPs were stabilized against crystal growth by electrostatic layer-by-layer (LBL) coating with various PAMAM dendrimers. Additionally, AgNPs can be incorporated in the dendrimer shells that augmented AgSD release. NP formulation in a cream base provided a topical drug-delivery platform with enhanced antibacterial properties against burn-wound infections, comprising three nanostructures i.e., nano-AgSD, AgNPs as well as PAMAM dendrimers, in one efficient, elegant nanosystemen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPAMAM dendrimeren_US
dc.subjectSilverantibiotic nanoparticlesen_US
dc.subjectSolubilityen_US
dc.subjectReleaseen_US
dc.subjectAntibacterialen_US
dc.titlePoly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activityen_US
dc.typeArticleen_US
dc.contributor.researchID10196226 - Liebenberg, Wilna
dc.contributor.researchID11333561 - Otto, Daniel Petrus
dc.contributor.researchID12428795 - Strydom, Schalk Johannes


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