dc.contributor.author | Du Toit, Trizel | |
dc.contributor.author | Malan, Maides M. | |
dc.contributor.author | Lemmer, Hendrik J.R. | |
dc.contributor.author | Gouws, Chrisna | |
dc.contributor.author | Aucamp, Marique E. | |
dc.contributor.author | Breytenbach, Wilma J. | |
dc.contributor.author | Hamman, Josias H. | |
dc.date.accessioned | 2016-07-25T07:16:39Z | |
dc.date.available | 2016-07-25T07:16:39Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Du Toit, T. et al. 2016. Combining chemical permeation enhancers for synergistic effects. European journal of drug metabolism and pharmacokinetics, 41(5):575-586. [https://doi.org/10.1007/s13318-015-0280-7] | en_US |
dc.identifier.issn | 0378-7966 | |
dc.identifier.issn | 2107-0180 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/18027 | |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs13318-015-0280-7 | |
dc.identifier.uri | https://doi.org/10.1007/s13318-015-0280-7 | |
dc.description.abstract | Currently, macromolecular drugs such as proteins
are mainly administered by means of injections due to
their low intestinal epithelial permeability and poor stability
in the gastrointestinal tract. This study investigated
binary combinations of chemical drug absorption enhancers
to determine if synergistic drug absorption enhancement
effects exist. Aloe vera, Aloe ferox and Aloe
marlothii leaf gel materials, as well as with N-trimethyl
chitosan chloride (TMC), were combined in different ratios
and their effects on the transepithelial electrical resistance
(TEER), as well as the transport of FITC-dextran across
Caco-2 cell monolayers, were measured. The isobole
method was applied to determine the type of interaction
that exists between the absorption enhancers combinations.
The TEER results showed synergism existed for the combinations
between A. vera and A. marlothii, A. marlothii
and A. ferox as well as A. vera and TMC. Antagonism
interactions also occurred and can probably be explained
by chemical reactions between the chemical permeation
enhancers, such as complex formation. In terms of FITCdextran
transport, synergism was found for combinations
between A. vera and A. marlothii, A. marlothii and A. ferox,
A. vera and TMC, A. ferox and TMC and A. marlothii and
TMC, whereas antagonism was observed for A. vera and A.
ferox. The combinations where synergism was obtained
have the potential to be used as effective drug absorption
enhancers at lower concentrations compared to the single
components | en_US |
dc.description.sponsorship | National Research Foundation of South Africa | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Negative Control Group | |
dc.subject | Permeation enhancer | |
dc.subject | Absorption enhancer | |
dc.subject | Iodomethane | |
dc.subject | Basolateral chamber | |
dc.title | Combining chemical permeation enhancers for synergistic effects | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 21649987 - Du Toit, Trizel | |
dc.contributor.researchID | 10187243 - Malan, Maides Maria | |
dc.contributor.researchID | 12450960 - Gouws, Chrisna | |
dc.contributor.researchID | 11927860 - Aucamp, Marique Elizabeth | |
dc.contributor.researchID | 10187081 - Breytenbach, Johanna Wilhelmina | |
dc.contributor.researchID | 10081097 - Hamman, Josias Hendrik | |
dc.contributor.researchID | 12932574 - Lemmer, Hendrik Jacobus Righard | |