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dc.contributor.authorMalan, Nico T.
dc.contributor.authorSmith, Wayne
dc.contributor.authorVon Känel, Roland
dc.contributor.authorHamer, Mark
dc.contributor.authorSchutte, Alta E.
dc.contributor.authorMalan, Leoné
dc.identifier.citationMalan, N.T. et al. 2015. Low serum testosterone and increased diastolic ocular perfusion pressure: a risk for retinal microvasculature. Vasa-european journal of vascular medicine, 44(6):435-443. []en_US
dc.description.abstractSummary: Background: Low levels of testosterone in men and changes in retinal microvascular calibre are both associated with hypertension and cardiovascular disease risk. Sex hormones are also associated with blood flow in microvascular beds which might be a key intermediate mechanism in the development of hypertension. Whether a direct association between endogenous testosterone and retinal microvascular calibre exists is currently unknown. We aimed to determine "whether testosterone is independently associated with ocular perfusion via a possible association with retinal vascular calibre or whether it plays only a secondary role via its effect on blood pressure in a bi–ethnic male cohort. Probands and methods: A total of 72 black and 81 white men (28–68 years of age) from the follow–up phase of the Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) study were included in this sub–study. Ambulatory pulse pressure and intraocular perfusion pressures were obtained, while metabolic variables and testosterone were measured from fasting venous blood samples. Retinal vascular calibre was quantified from digital photographs using standardised protocols." "Results: The black men revealed a poorer cardiometabolic profile and higher pulsatile pressure (> 50 mm Hg), intraocular" "pressure and diastolic ocular perfusion pressure than the white men (p ? 0.05). Only in the white men was free  testosterone positively associated with retinal calibre, i.e. arterio–venular ratio and central retinal arterial calibre and inversely with central retinal venular calibre. These associations were not found in the black men, independent of whether pulse pressure and ocular perfusion pressure were part of the model." "Conclusions: These results suggest an independent, protective effect of testosterone on the retinal vasculature where an apparent vasodilatory response in the retinal resistance microvessels was observed in white men.en_US
dc.publisherVerlag Hans Huber Hogrefe Agen_US
dc.subjectpulse pressureen_US
dc.subjectdiastolic ocular perfusion pressureen_US
dc.subjectintraocular pressureen_US
dc.subjectretinal microvascular calibreen_US
dc.titleLow serum testosterone and increased diastolic ocular perfusion pressure: a risk for retinal microvasculatureen_US
dc.contributor.researchID22684808 - Hamer, Mark
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID22945717 - Smith, Wayne

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