Browsing Research Output by Subject "Cancer"
Now showing items 1-10 of 12
-
Benzopyrone represents a privilege scaffold to identify novel adenosine A1/A2A receptor antagonists
(Elsevier, 2018)Adenosine receptor antagonists are under investigation as potential drug candidates for the treatment of certain cancers, neurological disorders, depression and potentially improve tumour immunotherapy. The benzo-γ-pyrone ... -
Cell-free DNA: preanalytical variables
(Elsevier, 2015)Since the discovery of cell-free DNA (cfDNA) in human blood, most studies have focused on diagnostic and prognostic uses of these markers for solid tumors. Except for some prenatal tests and BEAMing, cfDNA analysis has not ... -
A comparison between selected noncommunicable disease mortality rates between 2010 and 2016 among selected Southern African countries
(Sage, 2020)Researchers have identified cancer, diabetes mellitus, cardiovascular, and respiratory diseases as being the principal pathologies of increased aged standardized death rates (ASDRs) among noncommunicable diseases (NCDs). ... -
The development of a value based pricing index for new drugs in metastatic colorectal cancer
(Elsevier, 2011)Background Worldwide, prices for cancer drugs have been under downward pressure where several governments have mandated price cuts of branded products. A better alternative to government mandated price cuts would be to ... -
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro
(Elsevier, 2017)In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ... -
Indirect implications of COVID-19 prevention strategies on non-communicable diseases: an opinion paper of the European Society of Hypertension Working Group on Hypertension and Cardiovascular Risk Assessment in subjects living in or emigrating from low resource settings
(BMC, 2020)Background After its outbreak in China, the novel COronaVIrus Disease 19 is spreading across the globe. It is an emergency the world has never seen before. Main text The attention of health systems is mainly focused ... -
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
(BioMed Central, 2020)Background Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely ... -
Methodological variables in the analysis of cell-free DNA
(Springer, 2016)In recent years, cell-free DNA (cfDNA) analysis has received increasing amounts of attention as a potential non-invasive screening tool for the early detection of genetic aberrations and a wide variety of diseases, especially ... -
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ... -
Patient-family communication mediates the relation between family hardiness and caregiver positivity: exploring the moderating role of caregiver depression and anxiety
(Taylor & Francis, 2019)Purpose: Despite the theoretical and empirical significance of positive aspects of caregiving in caregiver well-being, relatively little is known regarding family-related predictors of caregiver positivity. This study ...