Browsing Research Output by Author "Badenhorst, Christoffel P.S."
Now showing items 1-4 of 4
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Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase
(Elsevier, 2013)Human glycine N-acyltransferase (human GLYAT) detoxifies a wide range of endogenous and xenobiotic metabolites, including benzoate and salicylate. Significant inter-individual variation exists in glycine conjugation capacity. ... -
The diverse origins of circulating cell‐free DNA in the human body: a critical re‐evaluation of the literature
(Wiley, 2018)Since the detection of cell‐free DNA (cfDNA) in human plasma in 1948, it has been investigated as a non‐invasive screening tool for many diseases, especially solid tumours and foetal genetic abnormalities. However, to date ... -
Enzymatic characterization and elucidation of the catalytic mechanism of a recombinant Bovine Glycine N-Acyltransferase
(ASPET, 2012)Glycine conjugation, a phase II detoxification process, is catalyzed by glycine N-acyltransferase (GLYAT; E.C. 2.3.1.13). GLYAT detoxifies various xenobiotics, such as benzoic acid, and endogenous organic acids, such as ... -
A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles
(Springer, 2016)The discovery of quantitative and qualitative differences of the circulating DNA (cirDNA) between healthy and diseased individuals inclined researchers to investigate these molecules as potential biomarkers for non-invasive ...