Browsing Research Output by Subject "Bioenhancer"

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Capsaicin and piperine as functional excipients for improved drug delivery across nasal epithelial models

Gerber, Werner; Steyn, Dewald; Kotzé, Awie; Svitina, Hanna; Weldon, Ché; Hamman, Josias (Thieme, 2019)

The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals isolated from different pepper species have been found to modulate ...
Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism

Peterson, Bianca; Weyers, Morné; Steenekamp, Jan H.; Steyn, Johan D.; Gouws, Chrisna; Hamman, Josias H. (MDPI, 2019)

Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ...