Browsing Research Output by Subject "Contractility"
Now showing items 1-2 of 2
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Considerations for an in vitro, cell-based testing platform for detection of adverse drug-induced inotropic effects in early drug development. Part 1: General considerations for development of novel testing platforms
(Frontiers Media, 2019)Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted ... -
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: a HESI-sponsored cross-company evaluation
(Elsevier, 2020)Introduction Alterations in cardiac contractility can have significant clinical implications, highlighting the need for early detection of potential liabilities. Pre-clinical methods to assess contractility are typically ...