Browsing Research Output by Subject "Mitochondria"
Now showing items 1-10 of 12
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A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
(Oxford Univ Press, 2018)Background Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ... -
Haplogroup context is less important in the penetrance of mitochondrial DNA complex I mutations compared to mt-tRNA mutations
(Springer, 2018)Mitochondrial diseases are a highly complex, heterogeneous group of disorders. Mitochondrial DNA variants that are linked to disease can exhibit variable expression and penetrance. This has an implication for mitochondrial ... -
Investigating the effects of the presence of foreign DNA on DNA methylation and DNA repair events in cultured eukaryotic cells
(Elsevier, 2013)Methylation of DNA in eukaryotic cells, global as well as gene-specific, is affected by endogenous and endogenous factors. In this paper, it is reported that deviations in DNA methylation and expression of genes involved ... -
Mitochondria are critical for BDNF-mediated synaptic and vascular plasticity of hippocampus following repeated electroconvulsive seizures
(Oxford Univ Press, 2018)Background Electroconvulsive therapy is a fast-acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections ... -
Mitochondrial DNA copy number is not associated with fatigue status in Primary Sjögren’s Syndrome
(Taylor & Francis, 2018)Background: Primary Sjögren’s syndrome (pSS) is a heterogeneous disease characterized by lymphocytic infiltrates to the exocrine glands, causing sicca symptoms and other manifestations. Fatigue is one of the most prominent ... -
Mitochondrial DNA replication and OXPHOS gene transcription show varied responsiveness to Rieske protein knockdown in 143B cells
(Elsevier, 2011)Genetic, biochemical and phenotypic diversity is a hallmark of OXPHOS deficiencies. Among the responses frequently reported for these deficiencies is differential expression of several genes involved in mitochondrial ... -
Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
(Wiley, 2013)Depressive disorders and the treatment thereof have been associated with a number of neuroplastic events, such as neurogenesis and synaptic remodeling in discrete areas of the brain. The associations of these events in ... -
Next generation sequencing of gonadal transcriptome suggests standard maternal inheritance of mitochondrial DNA in Eurhomalea rufa (Veneridae)
(Elsevier, 2017)Contrary to some of its relatives from Veneridae family, such as Venerupis philippinarium, the clam Eurhomalea rufa lacks doubly uniparental inheritance system of mitochondria. Here we present the argument for strict ... -
Novel mitochondrial and cytosolic purification pipeline for compartment-specific metabolomics in mammalian disease model tissues
(Springer, 2020)Introduction Mitochondria represent an important milieu for studying the pathogenesis of several major diseases. The need for organelle-level metabolic resolution exists, as mitochondrial/cytosolic metabolites are often ... -
OXPHOS gene expression and control in mitochondrial disorders
(Elsevier, 2009)The cellular consequences of deficiencies of the mitochondrial OXPHOS system include a variety of direct and secondary changes in metabolite homeostasis, such as ROS, Ca2+, ADP/ATP, and NAD/NADH. The adaptive responses to ...