Now showing items 1-2 of 2

    • A model of isoniazid treatment of tuberculosis 

      Lemmer, Yolandy; Grobler, Anne; Viljoen, Hendrik; Moody, Clint (Elsevier, 2014)
      A mathematical model is presented of the growth and death of bacilli in a granuloma. The granuloma is treated with isoniazid (INH), a drug that inhibits the synthesis of mycolic acids (MA). Since MA is an essential component ...
    • New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis 

      Loots, Du Toit (Oxford Univ Press, 2016)
      Objectives: Rifampicin is considered the most important antibiotic for treating TB, but unfortunately Mycobacterium tuberculosis is rapidly developing resistance to this drug. Despite the fervent research efforts to date, ...