Now showing items 1-2 of 2

    • Effects of oral administration of synthesized d-amides of eflornithine in the rat 

      Helena, Kevin J.; N'Da, David D.; Breytenbach, Jaco C.; Ashton, Michael; Johansson, Carl; Helena, Kevin J.; N'Da, David D.; Breytenbach, Jaco C.; Ashton, Michael; Johansson, Carl (Thieme, 2010)
      The purpose of this study was to synthesize a series of δ-amide derivatives of the antitrypanosomal drug eflornithine (2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride, DMFO, CAS 70052-12-9), to determine their ...
    • Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma 

      Cloete, Theunis T.; N'Da, David D.; Breytenbach, Jaco C.; Johansson, Carl C.; Kumar Vodnala, Suman; Cloete, Theunis T.; N'Da, David D.; Breytenbach, Jaco C.; Johansson, Carl C.; Kumar Vodnala, Suman (Thieme, 2011)
      The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their ...