Now showing items 1-3 of 3

    • Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives 

      Cilliers, Pieter; Smit, Frans J.; Aucamp, Janine; N'Da, David D.; Seldon, Ronnett (Wiley, 2019)
      Tuberculosis is the deadliest infectious disease affecting humankind with a death toll of approximately 1.7 million people in 2016. The increasing prevalence of multidrug‐resistant strains of the causative pathogen, ...
    • Synthesis and in vitro biological evaluation of aminoacridines and artemisinin-acridine hybrids 

      Joubert, Juan P.; Smit, Frans J.; Du Plessis, Lissinda; N'Da, David D.; Smith, Peter J. (Elsevier, 2014)
      During this study, 9-aminoacridine and artemisinin–acridine hybrid compounds were synthesized and the in vitro for antimalarial activity against both the chloroquine sensitive but also gametocytocidal strain (NF54), and ...
    • Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids 

      Lombard, Marli C.; N'Da, David D.; Breytenbach, Jaco C.; Smith, Peter J.; Lategan, Carmen A.; Lombard, Marli C.; N'Da, David D.; Breytenbach, Jaco C.; Smith, Peter J.; Lategan, Carmen A. (Elsevier, 2011)
      Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ...