Now showing items 1-5 of 5

    • Antioxidant properties of 4-quinolones and structurally related flavones 

      Greeff, Jane; Van Dyk, Sandra; Malan, Sarel F.; Joubert, Jacques; Greeff, Jane; Van Dyk, Sandra; Malan, Sarel F.; Joubert, Jacques (Elsevier, 2012)
      Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodegeneration may therefore ...
    • Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition 

      Joubert, Jacques; Van Dyk, Sandra; Malan, Sarel F.; Joubert, Jacques; Van Dyk, Sandra; Malan, Sarel F. (Elsevier, 2008)
      In recent years polycyclic compounds have been shown to exhibit pharmacological profiles of importance in the symptomatic and proposed curative treatment of neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s ...
    • Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents 

      Zindo, Frank T.; Barber, Quinton R.; Bergh, Jacobus J.; Petzer, Jacobus P.; Malan, Sarel F. (Elsevier, 2014)
      The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms which would ultimately inhibit N-methyl-D-aspartate (NMDA) receptors, block L-type voltage gated calcium channels (VGCC) ...
    • S-nitrosylation and attenuation of excessive calcium flux by pentacycloundecane derivatives 

      Lemmer, Hendrik J.R.; Joubert, Jacques; Van Dyk, Sandra; Van der Westhuizen, Francois H.; Malan, Sarel F.; Lemmer, Hendrik J.R.; Joubert, Jacques; Van Dyk, Sandra; Van der Westhuizen, Francois H.; Malan, Sarel F. (Bentham Science, 2012)
      A novel series of polycyclic amines, containing nitrogen monoxide donating moieties, were synthesised and tested for calcium channel and N-methyl-D-aspartate receptor modulating activity. The synthesised compounds were ...
    • Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents 

      Joubert, Jacques; Van Dyk, Sandra; Malan, Sarel F.; Green, Ivan R.; Joubert, Jacques; Van Dyk, Sandra; Malan, Sarel F.; Green, Ivan R. (Elsevier, 2011)
      A series of fluorescent heterocyclic adamantane amines were synthesised with the goal to develop novel fluorescent ligands for neurological assay development. These derivatives demonstrated multifunctional neuroprotective ...