Browsing Research Output by Subject "Safety pharmacology"
Now showing items 1-4 of 4
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Cardiovascular safety pharmacology studies in dogs enabled for a poorly soluble molecule using spray-dried dispersion: impact on lead selection
(Elsevier, 2016)The aim of this study was to identify an adequate formulation for a poorly soluble lead molecule (BI-A) that would achieve sufficiently high plasma concentrations after oral administration in dogs to enable a robust ... -
Drug safety Africa: an overview of safety pharmacology & toxicology in South Africa
(Elsevier, 2019)This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20–22, 2018 at the North-West University campus. There were 134 attendees (including ... -
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: a HESI-sponsored cross-company evaluation
(Elsevier, 2020)Introduction Alterations in cardiac contractility can have significant clinical implications, highlighting the need for early detection of potential liabilities. Pre-clinical methods to assess contractility are typically ... -
GLP in safety pharmacology studies: report card after 15 years
(Elsevier, 2017)The pivotal role of safety pharmacology in the safety testing of new drugs is now well established, having received a large impetus through the regulatory requirement of this type of study and the appearance of the ICHS7A ...