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Activities of 11-azaartemisinin and N-sulfonyl derivatives against asexual and transmissible malaria parasites
(Wiley, 2017)
Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clinical use—artemether and artesunate—induces quiescence in ring-stage parasites of ...
Activities of 11-azaartemisinin and N-sulfonyl derivatives against Neospora caninum and comparative cytotoxicities
(Wiley, 2017)
Neosporosis caused by the apicomplexan parasite Neospora caninum is an economically important disease that induces abortion in dairy and beef cattle. There are no vaccines or drugs available on the market for control or ...
Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives
(Elsevier, 2014)
Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and ...
Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro
(American Society for Microbiology, 2014)
The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability
to induce dormancy in Plasmodium falciparum. There was no increase in the activity of ...
Artemisone inhibits in vitro and in vivo propagation of Babesia bovis and B. bigemina parasites
(Elsevier, 2013)
Artemisone was evaluated, in in vitro and in vivo, for control of bovine babesiosis caused by Babesia
bigemina and Babesia bovis parasites. In vitro, artemisone reduced parasitemia in a dose-dependent manner:
the inhibitory ...
Anticancer properties of distinct antimalarial drug classes
(PLoS, 2013)
We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a
panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and ...
In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
(Elsevier, 2015)
Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalise on the last property, ...
In vitro skin permeation of artemisone and its nano-vesicular formulations
(Elsevier, 2016)
The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid
lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such
formulations ...
Methylene homologues of artemisone: an unexpected structure-activity relationship and a possible implication for the design of C10-substituted artemisinins
(Wiley, 2016)
We sought to establish if methylene homologues of artemisone are biologically more active and more stable than artemisone. The analogy is drawn with the conversion of natural O- and N-glycosides into more stable C-glycosides ...
Anti-melanoma activities of artemisone and prenylated amino-artemisinins in combination with known anticancer drugs
(Frontiers Media, 2020)
The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy have been achieved in certain cases, though only marginal advances ...