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The effect of temperature and moisture on the amorphous-to-crystalline transformation of stavudine
(Elsevier, 2009)
Stavudine is a nucleoside reverse transcriptase inhibitor active against HIV, and is known to exist in two polymorphic forms designated as forms I and II, and a hydrate form III. An amorphous solid of stavudine was ...
Physicochemical properties of amorphous roxithromycin prepared by quench cooling of the melt or desolvation of a chloroform solvate
(Springer, 2012)
Roxithromycin is a poorly soluble antibacterial drug. The aim of this study was to prepare and characterize an amorphous form of roxithromycin. The amorphous form was prepared by desolvation of its chloroform solvate, and ...
Effects of the cosurfactant 1-butanol and feed composition on nanoparticle properties
(Wiley, 2008)
The concentration of the cosurfactant 1-butanol (BuOH) determined the polymer weight and size for a series of poly(styrene-co-methyl methacrylate)s (P(St-co-MMA)) synthesized by the free-radical (o/w) microemulsion technique. ...
Development of microporous drug-releasing films cast from artificial nanosized latexes of poly (styrebe-co-methyl methacrylate) or poly (styrene-co-ethyl methacylate)
(Elsevier, 2008)
Two sets of copolymers comprising of styrene and either methyl or ethyl methacrylate as comonomer were conveniently synthesized by microemulsion copolymerization. The purified materials were characterized by GPC-MALLS and ...
Amorphous sulfadoxine: a physical stability and crystallization kinetics study
(Springer Nature, 2016)
Poor aqueous solubility of drugs and the improvement thereof has always been a challenge for
the pharmaceutical industry.With this, one of the focuses of the pharmaceutical research scientist involves
investigating ...
Channel inclusion of primary alcohols in isostructural solvates of the antiretroviral nevirapine: an X-ray and thermal analysis study
(Springer, 2010)
X-ray structural and thermoanalytical data for a series of solvates 2–7 of the anti-HIV drug nevirapine containing primary alcohols CH3(CH2)nOH with n = 2–7 are reported. The structures of 2–7 are based on a common ...
Characterization of polymorph transformations that decrease the stability of tablets containing the who essential drug mebendazole
(Elsevier, 2010)
This study investigated the influence of moisture and heat on the stability of mebendazole polymorph C in tablets. The polymorphic forms of mebendazole display significant differences in solubility and therapeutic efficacy ...
Preparation and characterization of directly compactible layer-by-layer nanocoated cellulose
(Elsevier, 2011)
Microcrystalline cellulose is a commonly used direct compression tablet diluent and binder. It is derived from purified α-cellulose in an environmentally unfriendly process that involves mineral acid catalysed hydrolysis. ...
Preparation and transformation of true nifedipine polymorphs: investigated with differential scanning calorimetry and X-Ray diffraction pattern fitting methods
(Elsevier, 2011)
The amorphous → metastable and metastable → stable crystalline phase transitions of nifedipine and their relationship with polymorph composition during storage at controlled temperature/humidity conditions were investigated. ...
Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates
(ACS, 2008)
Five crystalline solvates of the anti-HIV drug Nevirapine (N), with compositions N·(ethyl acetate)0.5 (1), N·(dichloromethane)0.5 (2), N·(toluene)0.5 (3), N·(water)0.5 (4), and N·(1,4-dioxane)1.5 (5), were isolated and ...