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Die identifisering van fenielbottersuur aromatiese metaboliete in die urien van die blou-aap
(Suid-Afrikaanse Akademie vir Wetenskap en Kuns, 2018)
Phenylbutyrate (PBA) is used as treatment of urea cycle disorders and as an alternative
treatment option for adrenoleykodystrophy, has neuroprotective
effects and provides
protection against oxidative stress. Known ...
Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid: a case report
(BioMed Central, 2011)
This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The
diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration
(VLCFA). ...
The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time
(Springer, 2011)
Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ...
Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase
(Elsevier, 2011)
In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate
(Springer, 2012)
Valproate administration increases the level of the
inhibitory transmitter, glycine, in the urine and plasma of
patients and experimental animals. Nonketotic hyperglycinemia
(NKH), an autosomal recessive disorder of ...
Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles
(Elsevier, 2008)
1-Methyl-3-phenyl-3-pyrrolines are structural analogues of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and like MPTP are selective substrates of monoamine oxidase B (MAO-B). As part of an ongoing ...
Imidazo[1,2-α]pyridines possess adenosine A1 receptor affinity for the potential treatment of cognition in neurological disorders
(Elsevier, 2017)
Previous research has shown that bicyclic 6:5-fused heteroaromatic compounds with two N-atoms have variable degrees of adenosine A1 receptor antagonistic activity. Prompted by this imidazo[1,2-α]pyridine analogues were ...
2-Benzylidene-1-indanone analogues as dual adenosine A1/A2a receptor antagonists for the potential treatment of neurological conditions
(Thieme, 2019)
Previous studies explored 2-benzylidine-1-tetralone derivatives as innovative adenosine A1 and A2A receptor antagonists for alternative non-dopaminergic treatment of Parkinson’s disease. This study’s aim is to investigate ...
Synthesis and evaluation of methoxy substituted 2-benzoyl-1-benzofuran derivatives as lead compounds for the development adenosine A1 and/or A2A receptor antagonists
(Elsevier, 2020)
A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were synthesised and their affinities determined for adenosine A1 and A2A receptors via radioligand binding assays to establish the structure ...
Die adenosien A1- en A2A-reseptoraffiniteit van ’n reeks 3,4-dihidropirimidoon-analoë
(AOSIS, 2017)
Parkinson se siekte is ’n komplekse neurodegeneratiewe siektetoestand. Huidige
behandeling van dié siekte is slegs op simptomatiese verligting gemik, sonder dat die
siekteverloop vertraag of gestop word. Sedert die ...