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Anti-melanoma activities of artemisone and prenylated amino-artemisinins in combination with known anticancer drugs
(Frontiers Media, 2020)
The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy have been achieved in certain cases, though only marginal advances ...
Reference gene selection for in vitro cell-free DNA analysis and gene expression profiling
(Elsevier, 2016)
Objectives: (i) To optimize cell-free DNA (cfDNA) and mRNA quantification using eight housekeeping genes
(HKGs), (ii) to determine if there is a difference in the occurrence of HKGs in the cfDNA andmRNA of normal cells
and ...
Preliminary evaluation of artemisinin-cholesterol conjugates as potential drugs for the treatment of intractable forms of malaria and tuberculosis
(Wiley, 2018)
To evaluate the feasibility of developing drugs that may be active against both malaria and tuberculosis (TB) by using in part putative cholesterol transporters in the causative pathogens and through enhancement of passive ...
Antimicrobial peptides: the Achilles’ heel of antibiotic resistance?
(Springer, 2018)
Antibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is coming to an end, and the ...
Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids
(Elsevier, 2018)
Artemisinin-ferrocene conjugates incorporating a 1,2-disubstituted ferrocene analogous to that embedded in ferroquine but attached via a piperazine linker to C10 of the artemisinin were prepared from the piperazine artemisinin ...
Assessing the DNA methylation status of single cells with the comet assay
(Elsevier, 2010)
The comet assay (single cell gel electrophoresis) is a cost-effective, sensitive, and simple technique that is traditionally used for analyzing and quantifying DNA damage in individual cells. The aim of this study was to ...
A quantitative assessment of cell-free DNA utilizing several housekeeping genes: measurements from four different cell lines
(Springer, 2016)
Quantitative real-time PCR (qPCR) is regularly used to quantify cell-free nucleic acids (cfNAs) in order to identify biomarkers for various pathologies. However, studies have shown notable housekeeping gene expression ...
Using a medium-throughput comet assay to evaluate the global DNA methylation status of single cells
(Frontiers Media, 2014)
The comet assay is a simple and cost effective technique, commonly used to analyze and quantify DNA damage in individual cells. The versatility of the comet assay allows introduction of various modifications to the basic ...
Synthesis, in vitro antimalarial activities and cytotoxicities of amino-artemisinin-ferrocene derivatives
(Elsevier, 2018)
Novel derivatives bearing a ferrocene attached via a piperazine linker to C-10 of the artemisinin nucleus were prepared from dihydroartemisinin and screened against chloroquine (CQ) sensitive NF54 and CQ resistant K1 and ...
An enquiry concerning the characteristics of cell-free DNA released by cultured cancer cells
(Springer, 2016)
Non-invasive screening that utilizes cell-free DNA (cfDNA) offers remarkable potential as a method for the early detection of genetic disorders and a wide variety of cancers. Unfortunately, one of the most prominent elements ...