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Kinetic analysis, size profiling, and bioenergetic association of DNA released by selected cell lines in vitro
(Springer, 2017)
Although circulating DNA (cirDNA) analysis shows great promise as a screening tool for a wide range of pathologies, numerous stumbling blocks hinder the rapid translation of research to clinical practice. This is related ...
Cell-free DNA in a three-dimensional spheroid cell culture model: a preliminary study
(Elsevier, 2017)
Background
Investigating the biological functions of cell-free DNA (cfDNA) is limited by the interference of vast numbers of putative sources and causes of DNA release into circulation. Utilization of three-dimensional ...
A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles
(Springer, 2016)
The discovery of quantitative and qualitative
differences of the circulating DNA (cirDNA) between
healthy and diseased individuals inclined researchers to
investigate these molecules as potential biomarkers for
non-invasive ...
Valproic acid alters the content and function of the cell-free DNA released by hepatocellular carcinoma (HepG2) cells in vitro
(Elsevier, 2017)
Background
It has long been believed that cell-free DNA (cfDNA) actively released into circulation can serve as intercellular messengers, and their involvement in processes such as the bystander effect strongly support ...
The diverse origins of circulating cell‐free DNA in the human body: a critical re‐evaluation of the literature
(Wiley, 2018)
Since the detection of cell‐free DNA (cfDNA) in human plasma in 1948, it has been investigated as a non‐invasive screening tool for many diseases, especially solid tumours and foetal genetic abnormalities. However, to date ...