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Solution-mediated phase transformation of different roxithromycin solid-state forms: implications on dissolution and solubility
(Elsevier, 2013)
The objective of this study was to describe the solid-state forms in which roxithromycin may exist and
the significant influence of solution-mediated phase transformation on the dissolution and solubility
behavior of ...
Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study
(Elsevier, 2016)
The striking impact that different preparation methods have on the characteristics of amorphous solidstate
forms has attracted considerable attention during the last two decades. The pursuit of more
extensive knowledge ...
The stabilization of amorphous zopiclone in an amorphous solid dispersion
(Springer, 2015)
Zopiclone is a poorly soluble psychotherapeutic agent. The aim of this study was to prepare and
characterize an amorphous form of zopiclone as well as the characterization and performance of a stable
amorphous solid ...
Amorphous azithromycin with improved aqueous solubility and intestinal membrane permeability
(Taylor & Francis, 2015)
Azithromycin (AZM) is a poorly soluble macrolide antibacterial agent. Its low solubility is
considered as the major contributing factor to its relatively low oral bioavailability. The aim of
this study was to improve the ...
Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies-activities against blood stage P. falciparum including PfKI3 C580Y mutants and liver stage P. berghei parasites
(Frontiers, 2020)
We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives ...
Influence of the composition of water/ethanol mixtures on the solubility and recrystallization of nevirapine
(ACS, 2010)
Anhydrous nevirapine was recrystallized from ethanol containing various amounts of water to determine its effects on the products obtained. The solubility of the anhydrous form was determined for each of the binary solvent ...
Channel inclusion of primary alcohols in isostructural solvates of the antiretroviral nevirapine: an X-ray and thermal analysis study
(Springer, 2010)
X-ray structural and thermoanalytical data for a series of solvates 2–7 of the anti-HIV drug nevirapine containing primary alcohols CH3(CH2)nOH with n = 2–7 are reported. The structures of 2–7 are based on a common ...
Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles
(Elsevier, 2014)
A layer-by-layer (LbL) nanocoat (b25 nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was
self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification
method ...
Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity
(Elsevier, 2013)
Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine)
(PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up ...
Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour
(RSC, 2012)
Synthesis and physicochemical characterization of co-crystals of the antiretroviral drug nevirapine (NV) with the pharmaceutically acceptable co-formers saccharin, rac-tartaric acid, maleic acid, glutaric acid and salicylic ...