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Coping facilitated troponin T increases and hypo-responsivity in the copeptin-HPA-axis during acute mental stress in a black cohort: the SABPA study
(Elsevier, 2019)
Background
Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an ...
BDNF increases associated with constant troponin T levels and may protect against poor cognitive interference control: the SABPA prospective study
(Wiley, 2019)
Background: Brain‐derived neurotrophic factor (BDNF) modulates brain health and cognition, which can interfere with executive cognitive function. BDNF was impli-cated with microcirculatory ischaemia and may reflect ...
Retinal vasculature reactivity during flicker light provocation, cardiac stress and stroke risk in Africans: the SABPA study
(Springer, 2019)
Structural and functional similarities exist between the retinal, cerebral and, as previously suggested, the coronary microvasculature. Retinal microvascular structure and functionality (in response to flicker-light-indu ...
Copeptin relates to a fatty liver and measures of obesity in a South African population with mixed ethnicities
(Springer, 2019)
Purpose
Elevated copeptin, a vasopressin marker, is linked to metabolic disease, and obese rats with low-vasopressin concentration had a decreased risk of liver steatosis. We here investigated the association between ...
Implementing a new variant load model to investigate the role of mtDNA in oxidative stress and inflammation in a bi-ethnic cohort: the SABPA study
(Taylor & Francis, 2019)
Mitochondrial DNA (mtDNA) variation has been implicated in several common complex and degenerative diseases, including cardiovascular disease. Inflammation is seen as part of many of these conditions. Mitochondria feature ...
Longitudinal changes of cardiac troponin and inflammation reflect progressive myocyte stretch and likelihood for hypertension in a Black male cohort: the SABPA study
(Springer, 2019)
Inflammation was cross-sectionally associated with subclinical wall remodeling and hypertension. Whether longitudinal changes (∆) in inflammation, myocyte injury (troponin T), and stretch (N-terminal-pro-B-type natriuretic ...
Stress and neurovascular coupling: a red flag? The SABPA study
(Karger, 2019)
Neuronal hyperactivity mediates communication between neurons and blood vessels (neurovascular coupling) and increases susceptibility for retinal ganglion
cells functionality. Contrastingly, monoamine depletion and ...
Heart rate variability and the dynamic nature of the retinal microvasculature: providing insight into the brain-retina-heart link: the SABPA study
(Karger, 2019)
Controversy exists regarding the contribution of
the autonomic nervous system (ANS) to the retinal microvasculature’s autoregulatory capacities. It was demonstrated that mean
retinal vessel responses to systemic sympathetic ...
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study
(Karger, 2019)
Assessment of the retinal vessels’ structure and
function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature
and indicates susceptibility for stroke. ...
Ethnicity-specific changes in cardiac troponin t in response to acute mental stress and ethnicity-specific cutpoints for the R wave of the aVL lead: the SABPA study
(Oxford Univ Press, 2019)
Acute mental stressor–induced cardiac stress responses might contribute to excessive myocardial strain and resultant cardiovascular episode risk. We assessed ethnicity-specific acute cardiac stress (by measuring cardiac ...