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The cardiotonic steroid marinobufagenin is a predictor of increased left ventricular mass in obesity: the African-PREDICT study
(MDPI, 2020)
The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in ...
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
(Nature, 2020)
Hypertension is common in black populations and is known to be associated with low nitric oxide (NO) bioavailability. We compared plasma and urinary NO-related markers and plasma creatine kinase (CK) levels between young ...
Phenotypic predictors of aortic root dilation in essential hypertension
(Sage, 2020)
Several life-threatening complications can develop in
the ascending aorta, which include dissection or rupture of an aortic aneurysm. Those at high risk of developing such complications can be categorised according
to ...
Left ventricular mass and urinary metabolomics in young black and white adults: the African-PREDICT study
(Elsevier, 2020)
Background and aims
Increased left ventricular mass is an independent predictor for cardiovascular events, and shown to be higher in black than white populations. To gain a better understanding of early factors contributing ...
Adiposity and physical activity are related to heart rate variability: the African-PREDICT study
(Wiley, 2020)
Background
Physical inactivity contributes significantly to the development of obesity‐related cardiovascular disease. Adiposity may lead to reduced heart rate variability (HRV), whereas increased physical activity (PA) ...
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
(Springer, 2020)
Nitric oxide plays an important role in maintaining endothelial function, while increased oxidative stress may lead to nitric oxide inactivation and cardiovascular disease. If nitric oxide biosynthesis/bioavailability is ...
Growth differentiating factor-15 and its association with traditional cardiovascular risk factors: the African-PREDICT study.
(Elsevier, 2020)
Background and aims
Growth differentiating factor-15 (GDF-15) is a stress-induced and cardio-protective cytokine, reported to be influenced by a number of cardiovascular risk factors. In older adults, GDF-15 associated ...
An ethnic comparison of arginine dimethylation and cardiometabolic factors in healthy black and white youth: the ASOS and African-PREDICT studies
(MDPI, 2020)
Proteinic arginine dimethylation (PADiMe) is a major post-translational modification. Proteolysis of asymmetric and symmetric PADiMe products releases asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), ...
The Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN Youth SA)
(Frontiers Media, 2020)
Background: The impact of a sedentary and unhealthy lifestyle on cardiovascular
health is well-documented, however the current obesity and hypertension trends among
children is concerning. The ExAMIN Youth SA study aims ...
Highlights from the International Society of Hypertension's New Investigators Network during 2019
(Wolters Kluwer Health, 2020)
The New Investigators Committee (NIC) of the International Society of Hypertension (ISH) is a dynamic group of junior doctors and scientists, actively involved in various society activities. This report highlights the ...