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Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxice synthase inhibitors
(Elsevier, 2009)
Monoamine oxidase B (MAO-B) and nitric oxide synthase (NOS) have both been implicated in the pathology of neurodegenerative diseases. In an attempt to design dual-target-directed drugs that inhibit both these enzymes, a ...
Fluorescent polycyclic ligands for nitric oxide synthase (NOS) inhibition
(Elsevier, 2008)
In recent years polycyclic compounds have been shown to exhibit pharmacological profiles of importance in the symptomatic and proposed curative treatment of neurodegenerative diseases (e.g., Parkinson’s and Alzheimer’s ...
Nitric oxide syntase inhibition by pentacycloundecane conjugates of aminoguanidine and tryptamine
(Wiley, 2009)
This paper describes the synthesis and in-vitro activity of pentacycloundecane-conjugated aminoguanidine
and tryptamine analogues on nitric oxide synthase (NOS) using rat brain homogenate.
Both aminoguanidine and ...