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Metabolomics and personalized medicine
(Elsevier, 2016)
Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of diseases using methods determined and averaged for the specific diseased cohort/population. Although this approach complies positively ...
Polyunsaturated fatty acid status in treated isovaleric acidemia patients
(Springer Nature, 2016)
BACKGROUND/OBJECTIVES: Nutritional deficiencies are frequently observed when treating patients with inborn errors of
metabolism due to an unbalanced diet. Thus far, patients with isovaleric acidemia (IVA) who adhere to a ...
A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria
(Elsevier, 2016)
The ESX-1 gene cluster, encoding the Type-VII secretion (T7S) system and its virulence associated proteins, ESAT-6 and CFP-10, is thought to be responsible for the transport of extracellular proteins across the hydrophobic ...
New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis
(Oxford Univ Press, 2016)
Objectives: Rifampicin is considered the most important antibiotic for treating TB, but unfortunately Mycobacterium tuberculosis is rapidly developing resistance to this drug. Despite the fervent research efforts to date, ...
Can a metabolomics-based approach be used as alternative to analyse fatty acid methyl esters from soil microbial communities?
(Elsevier, 2016)
Modern high-throughput approaches such as metabolomics, holds promise for investigating microbial communities. This study evaluated the quantitative and qualitative data generation potential of a metabolomics-based approach ...