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GC-MS-based urinary organic acid profiling reveals multiple dysregulated metabolic pathways following experimental acute alcohol consumption
(Nature, 2018)
Metabolomics studies of diseases associated with chronic alcohol consumption provide compelling evidence of several perturbed metabolic pathways. Moreover, the holistic approach of such studies gives insights into the ...
Metabolomics variable selection and classification in the presence of observations below the detection limit using an extension of ERp
(BioMed Central, 2017)
Background
ERp is a variable selection and classification method for metabolomics data. ERp uses minimized classification error rates, based on data from a control and experimental group, to test the null hypothesis of ...
A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls
(BioMed Central, 2017)
Background:
Fibromyalgia syndrome (FMS) is a chronic pain syndrome. A plausible pathogenesis of the disease is
uncertain and the pursuit of measurable biomarkers for objective identification of affected individuals is a ...
Concurrent class analysis identifies discriminatory variables from metabolomics data on isovaleric acidemia
(Springer, 2012)
Metabolomics data are typically complex and high dimensional. Multivariate dimension-reducing techniques have thus been developed for analysing metabolomics data to disclose underlying relationships, with principal component ...
Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach
(Springer, 2013)
The diagnosis of respiratory chain deficiencies
(RCDs) is complicated and the need for a diagnostic biomarker
or biosignature has been widely expressed. In this
study, the metabolic profile of a selected group of 29 ...
Metabolomics of urinary organic acids in respiratory chain deficiencies in children
(Springer, 2012)
Metabolomic analysis of the urinary organic
acids from 39 selected children with defined respiratory
chain deficiencies (RCDs) was performed using untargeted
gas chromatography–mass spectrometry, revealing the
presence ...