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Uncovering the metabolic response of abalone (Haliotis midae) to environmental hypoxia through metabolomics
(Springer, 2018)
Introduction
Oxygen is essential for metabolic processes and in the absence thereof alternative metabolic pathways are required for energy production, as seen in marine invertebrates like abalone. Even though hypoxia has ...
Metabolomics reveals the depletion of intracellular metabolites in HepG2 cells after treatment with gold nanoparticles
(Taylor & Francis, 2018)
Studies on the safety of gold nanoparticles (GNPs) are plentiful due to their successful application in drug delivery and treatment of diseases in trials. Cytotoxicity caused by GNPs has been studied on the physiological ...
Miniaturized 1H-NMR method for analyzing limited-quantity samples applied to a mouse model of Leigh disease
(Springer, 2018)
Introduction
The analysis of limited-quantity samples remains a challenge associated with mouse models, especially for multi-platform metabolomics studies. Although inherently insensitive, the highly specific characteristics ...
Metabolomics and personalized medicine
(Elsevier, 2016)
Current clinical practice strongly relies on the prognosis, diagnosis, and treatment of diseases using methods determined and averaged for the specific diseased cohort/population. Although this approach complies positively ...
Gas chromatography-mass spectrometry profiles of urinary organic acids in healthy captive cheetahs ( Acinonyx jubatus )
(Elsevier, 2017)
In captivity, cheetahs (Acinonyx jubatus) frequently suffer from several unusual chronic diseases that rarely occur in their free-ranging counterparts. In order to develop a better understanding of their metabolism and ...
Polyunsaturated fatty acid status in treated isovaleric acidemia patients
(Springer Nature, 2016)
BACKGROUND/OBJECTIVES: Nutritional deficiencies are frequently observed when treating patients with inborn errors of
metabolism due to an unbalanced diet. Thus far, patients with isovaleric acidemia (IVA) who adhere to a ...
A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS)
(Elsevier, 2019)
We used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke like episodes (MELAS) cohorts carrying the m.3243A>G mutation.
The ...
Fatty acid metabolome extraction from mycobacterial cells for GC-MS metabolomics analysis
(Humana, 2019)
Metabolomics is becoming an increasingly popular research tool for identifying new biomarkers, which can, among other applications, be applied to elucidate various microbial growth and virulence mechanisms. Since the lipid ...
Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise
(Springer, 2013)
Metallothioneins (MTs) are ubiquitous, multifunctional
proteins with key roles in metal homeostasis and
redox regulation. Their involvement in cellular energy
metabolism is evident from the observation that metallothi ...
The application of metabolomics toward pulmonary tuberculosis research
(Elsevier, 2019)
In the quest to identify novel biomarkers for pulmonary tuberculosis (TB), high-throughput systems biology approaches such as metabolomics has become increasingly widespread. Such biomarkers have not only successfully been ...