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Inhibition of monoamine oxidase by 3,4-dihydro-2(1H)-quinolinone derivatives
(Elsevier, 2013)
In the present study, a series of 3,4-dihydro-2(1H)-quinolinone derivatives were synthesized and evaluated
as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 3,4-dihydro-2(1H)-
quinolinone derivatives ...
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(Elsevier, 2015)
Studies have shown that natural and synthetic chalcones (1,3-diphenyl-2-propen-1-ones) possess monoamine oxidase (MAO) inhibition activities. Of particular importance to the present study is a report that a series of ...
Caffeine as a lead compound for the design of therapeutic agents for the treatment of Parkinson’s disease
(Bentham Science, 2015)
The current pharmacological therapies for the treatment of Parkinson’s disease are mostly inadequate and recent, improved therapeutic agents are required. Two important molecular targets for the design of anti-parkinsonian ...
2-Aminopyrimidines as dual adenosine A1/A2A antagonists
(Elsevier, 2015)
In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this ...
3-Coumaranone derivatives as inhibitors of monoamine oxidase
(Dove Press, 2015)
The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents
(Elsevier, 2014)
The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms
which would ultimately inhibit N-methyl-D-aspartate (NMDA) receptors, block L-type voltage gated
calcium channels (VGCC) ...
New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies
(Elsevier, 2014)
Although there are clinical trials and in vivo studies in literature regarding the anxiolytic and antidepressant
activities of the components of Crocus sativus L., their effects on the human monoamine oxidases
(hMAO-A ...
Inhibition of monoamine oxidase by selected phenylalkylcaffeine analogues
(Wiley, 2014)
Objectives Caffeine represents a useful scaffold for the design of monoamine
oxidase (MAO) type B inhibitors. Specifically, substitution on the C8 position
yields structures which are high-potency MAO-B inhibitors. To ...
The interactions of azure B, a metabolite of methylene blue, with 2 acetylcholinesterase and butyrylcholinesterase
(Elsevier, 2014)
Methylene blue(MB) is reported to possess diverse pharmacological actions and is attracting increasing attention
for the treatment of neurodegenerative disorders such as Alzheimer's disease. Among the pharmacological
actions ...
α-Tetralone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2014)
In the present study, a series of fifteen a-tetralone (3,4-dihydro-2H-naphthalen-1-one) derivatives were
synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The
a-tetralone ...