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The Na+K+-ATPase inhibitor marinobufagenin and early cardiovascular risk in humans: a review of recent evidence
(Springer, 2019)
Purpose of Review
This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na+/K+-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular ...
Heart rate variability and the dynamic nature of the retinal microvasculature: providing insight into the brain-retina-heart link: the SABPA study
(Karger, 2019)
Controversy exists regarding the contribution of
the autonomic nervous system (ANS) to the retinal microvasculature’s autoregulatory capacities. It was demonstrated that mean
retinal vessel responses to systemic sympathetic ...
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study
(Karger, 2019)
Assessment of the retinal vessels’ structure and
function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature
and indicates susceptibility for stroke. ...
The oxidative stress profile and its relation to vascular function in a bi-ethnic cohort: the SABPA study
(Karger, 2019)
Oxidative stress and inflammation
has been implicated in arterial stiffness, and hypertension development. Oxidative stress may interfere with normal vascular function by inactivation of NO and/or the production of ...
Retinal vessel caliber and vessel reaction to light flicker in true normotensive young healthy black and white adults: the African-PREDICT study
(Karger, 2019)
A detrimental shift in cardiovascular disease risk
factors and a higher mortality level are reported in some black
populations. The retinal microvasculature provides insight into
the pathogenesis of systemic vascular ...
Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT study
(Nature, 2018)
Marinobufagenin (MBG) is an endogenous steroidal α1-Na+K+-ATPase inhibitor. Because of its role in sodium handling, MBG has been associated with both antihypertensive and prohypertensive effects in normal physiology and ...
Inter-arm blood pressure difference and its relationship with retinal microvascular calibres in young individuals: the African-PREDICT study
(Elsevier Science Inc, 2016)
Background
Bilateral systolic blood pressure (SBP) differences > 10 mmHg is a common finding in clinical practice. Such BP differences in older individuals are associated with peripheral vascular disease, linked to ...
Dependence of cardiac systolic function on elevated fatty acid availability in obese, insulin-resistant rats
(Elsevier, 2016)
Background
Clinical data advocating an adverse effect of obesity on left ventricular (LV) systolic function independent of comorbidities is controversial. We hypothesized that in obesity with prediabetic insulin resistance, ...
Vitamin K dependent protection of renal function in multi-ethnic population studies
(Elsevier, 2016)
Background: Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but
its role in preserving renal function remains unknown.
Methods: In 1166white Flemish (mean age, 38.2 years) ...
Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study
(Sage Publications Ltd, 2016)
Background:
Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful
in predicting hypertension, carotid wall thickness and mortality. We determined the five-year ...