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Urinary metabolite markers characterizing tuberculosis treatment failure
(Springer, 2017)
Background
Considering that approximately 15% of the nine million new tuberculosis (TB) cases reported per annum are not treated successfully, new, distinctive and specific biomarkers are needed to better characterize the ...
The role of metabolomics in tuberculosis treatment research
(Future Medicine, 2017)
Despite the fact that tuberculosis (TB) is a curable disease, it still results in approximately 1.8 million deaths annually. Various inadequacies in the current TB treatment strategies are major contributors to this high ...
Using “omics” and integrated multi-omics approaches to guide probiotic selection to mitigate chytridiomycosis and other emerging infectious diseases
(Frontiers Media, 2016)
Emerging infectious diseases in wildlife are responsible for massive population declines. In amphibians, chytridiomycosis caused by Batrachochytrium dendrobatidis, Bd, has severely affected many amphibian populations and ...
Characterising the metabolic differences related to growth variation in farmed Haliotis midae
(Elsevier, 2018)
The South African abalone farming industry is entirely based on Haliotis midae, which has been commercially cultured with great success the last 20 years. Even though abalone are cultivated under identical farming conditions, ...
Metabolomic response to coffee consumption: application to a three‐stage clinical trial
(Wiley, 2018)
Background
Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development.
Objective
To identify individual metabolite changes in response to ...
Probiotic treatment reduces depressive-like behaviour in rats independently of diet
(Elsevier, 2017)
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive ...
Elucidating the antimicrobial mechanisms of colistin sulfate on Mycobacterium tuberculosis using metabolomics
(Elsevier, 2018)
Considering the disadvantageous of first line anti-tuberculosis (TB) drugs, including poor patient adherence, drug side effects, the long treatment duration and rapidly increasing microbe resistance, alternative treatment ...
Tween 80 induces a carbon flux rerouting in Mycobacterium tuberculosis
(Elsevier, 2020)
As a means to increase the growth rate and reduce aggregation, Tween 80 is routinely added to growth media during mycobacterial culturing. This detergent has, however, been associated with causing alterations to the ...