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Breaching the skin barrier through temperature modulations
(Elsevier, 2015)
The impermeability of the stratum corneum often hinders the transport of molecules across the skin. Temperature modulations in the skin and the application of local heat both have the potential of circumventing this problem ...
Penetration enhancing effects of selected natural oils utilized in topical dosage forms
(Taylor & Francis, 2015)
Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ...
Optimised transdermal delivery of pravastatin
(Elsevier, 2015)
Wiechers’ programme “Formulating for Efficacy” initiated a new strategy to optimise the oil phase of topical formulations in order to achieve optimal transdermal drug delivery. This new approach uses the “Delivery Gap ...
Skin permeation enhancement effects of the gel and whole 1 leaf materials of A. vera, A. marlothii and A. ferox
(Wiley, 2015)
Objectives: The aim of this study was to investigate the in vitro permeation enhancement effects of the gel and whole leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound. Methods: ...
Stability, clinical efficacy and antioxidant properties of honeybush extracts in semi-solid formulations.
(Medknow Publications, 2015)
Background: Honeybush extracts (Cyclopia spp.) can be incorporated into skin care products to treat conditions such as skin dryness and can function as an anti-oxidant. Objective: To formulate Honeybush formulations and ...
Topical delivery of 5-fluorouracil from Pheroid™ formulations and the in vitro efficacy against human melanoma
(Springer, 2015)
Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, ...
Vesicular carriers for skin drug delivery: the Pheroid™ technology
(Bentham Science, 2015)
The skin remains an attractive area for drug delivery. The skin, however, often limits the ingress of drugs, because of its very low permeability. Much research, focusing on employing a variety of physical and chemical ...