Now showing items 1-4 of 4
A metabolomics approach exploring the function of the ESX-3 type VII secretion system of M. smegmatis
The genome of Mycobacterium, including Mycobacterium tuberculosis, contains five copies of a cluster of genes encoding a novel type VII secretion system, named the ESX gene cluster region. This ESX-3 gene cluster is ...
Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise
Metallothioneins (MTs) are ubiquitous, multifunctional proteins with key roles in metal homeostasis and redox regulation. Their involvement in cellular energy metabolism is evident from the observation that metallothi ...
Disclosure of a putative biosignature for respiratory chain disorders through a metabolomics approach
The diagnosis of respiratory chain deficiencies (RCDs) is complicated and the need for a diagnostic biomarker or biosignature has been widely expressed. In this study, the metabolic profile of a selected group of 29 ...
New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa
In this study, a metabolomics research approach was used to identify new tuberculosis (TB) markers from sputum, in an attempt to better characterise the disease as well as the metabolic response of the host to Mycobacterium ...