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    The role of metabolomics in tuberculosis treatment research 

    Luies, Laneke; Du Preez, Ilse; Loots, Du Toit (Future Medicine, 2017)
    Despite the fact that tuberculosis (TB) is a curable disease, it still results in approximately 1.8 million deaths annually. Various inadequacies in the current TB treatment strategies are major contributors to this high ...
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    New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis 

    Loots, Du Toit (Oxford Univ Press, 2016)
    Objectives: Rifampicin is considered the most important antibiotic for treating TB, but unfortunately Mycobacterium tuberculosis is rapidly developing resistance to this drug. Despite the fervent research efforts to date, ...
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    Urinary metabolite markers characterizing tuberculosis treatment failure 

    Luies, Laneke; Mienie, Japie; Motshwane, Christinah; Loots, Du Toit; Ronacher, Katharina (Springer, 2017)
    Background Considering that approximately 15% of the nine million new tuberculosis (TB) cases reported per annum are not treated successfully, new, distinctive and specific biomarkers are needed to better characterize the ...
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    Predicting tuberculosis treatment outcome using metabolomics 

    Luies, Laneke; Van Reenen, Mari; Loots, Du Toit; Ronacher, Katharina; Walzl, Gerhard (Future Medicine, 2017)
    Aim: Predicting a poor treatment outcome would offer significant benefits for patient care and for new drug development. Materials, methods & results: Urine samples from tuberculosis-positive patients with a successful and ...
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    The application of metabolomics toward pulmonary tuberculosis research 

    Du Preez, Ilse; Luies, Laneke; Loots, Du Toit (Elsevier, 2019)
    In the quest to identify novel biomarkers for pulmonary tuberculosis (TB), high-throughput systems biology approaches such as metabolomics has become increasingly widespread. Such biomarkers have not only successfully been ...
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    Elucidating the antimicrobial mechanisms of colistin sulfate on Mycobacterium tuberculosis using metabolomics 

    Koen, Nadia; Loots, Du Toit; Van Breda, Shane Vontelin (Elsevier, 2018)
    Considering the disadvantageous of first line anti-tuberculosis (TB) drugs, including poor patient adherence, drug side effects, the long treatment duration and rapidly increasing microbe resistance, alternative treatment ...
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    Metabolomics of colistin methanesulfonate treated Mycobacterium tuberculosis 

    Koen, Nadia; Van Breda, Shane Vontelin; Loots, Du Toit (Elsevier, 2018)
    Over the past 5 years, there has been a renewed interest in finding new compounds with anti-TB action. Colistin methanesulfonate or polymyxin E, is a possible anti-TB drug candidate, which may in future be used either alone ...
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    A comparison of two extraction methods for differentiating and characterising various Mycobacterium species and Pseudomonas aeruginosa using GC-MS metabolomics 

    Olivier, Ilse; Loots, Du Toit (Academic Journals, 2012)
    We investigated the capacity of a metabolomics research approach to characterise and differentiate between various infectious Mycobacterium species and Pseudomonas aeruginosa, and compared two extraction procedures; 1) ...
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    New sputum metabolite markers implicating adaptations of the host to Mycobacterium tuberculosis, and vice versa 

    Du Preez, I.; Loots, D.T. (Elsevier, 2013)
    In this study, a metabolomics research approach was used to identify new tuberculosis (TB) markers from sputum, in an attempt to better characterise the disease as well as the metabolic response of the host to Mycobacterium ...
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    TB or not TB? Improving the understanding and diagnosis of tuberculosis through metabolomics 

    Loots, Du Toit (Future Medicine, 2016)
    “ ...metabolomics has resulted in an exponential increase in the number of newly identified tuberculosis biomarkers, which has not only shed light on previously unknown disease mechanisms, but could potentially ...
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    AuthorLoots, Du Toit (10)Luies, Laneke (5)Du Preez, Ilse (3)Koen, Nadia (2)Loots, Du Toit (2)Olivier, Ilse (2)Ronacher, Katharina (2)Van Breda, Shane Vontelin (2)Du Preez, I. (1)Gey, Van Pittius Nicolaas (1)... View MoreSubject
    Metabolomics (13)
    Tuberculosis (13)
    Biomarkers (5)Metabolites (4)Mycobacterium tuberculosis (4)Antibiotics (3)Treatment (3)Chemometrics (2)Diagnostics (2)M. tuberculosis (2)... View MoreDate Issued2019 (1)2018 (2)2017 (4)2016 (3)2013 (1)2012 (2)

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