Faculty of Health Sciences
Recent Submissions
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Early Vascular Ageing Phenotypes And Urinary Targeted Metabolomics In Children And Young Adults: The Examin Youth Sa And African-Predict Studies
(Springer, 2023)Some individuals are susceptible to accelerated biological ageing, resulting in premature alterations in arterial structure and function. Identifying early-onset vascular ageing characterised by arterial stifening is vital ... -
Detecting And Managing Childhood Onset Hypertension In Africa: A Call To Action
(Springer, 2023)Purpose of Review To review recent evidence on childhood hypertension across Africa, identifying knowledge gaps, challenges and priorities, and highlight clinical perspectives in managing primary hypertension. Recent ... -
Artemisia Species And Their Active Constituents For Treating Schistosomiasis
(Springer, 2023)Schistosomiasis, a neglected tropical disease, afects millions of lives and accounts for thousands of deaths each year. The Schistosoma parasites depend on two hosts during their lifecycle: snails as intermediate hosts ... -
Associations Between Nesting, Stereotypy, And Working Memory In Deer Mice: Response To Levetiracetam
(Springer, 2023)Background Some deer mice (Peromyscus maniculatus bairdii) exhibit various phenotypes of persistent behaviors. It remains unknown if and how said phenotypes associate with early-life and adult cognitive perturbations, and ... -
Markers Of Arterial Stiffness And Urinary Metabolomics In Young Adults With Early Cardiovascular Risk: The African-Predict Study
(Springer, 2023)ntroduction Increased exposure to risk factors in the young and healthy contributes to arterial changes, which may be accompanied by an altered metabolism. Objectives To increase our understanding of early metabolic ... -
Monoamine Oxidase Inhibition Properties Of 2,1-Benzisoxazole Derivatives
(Springer, 2023)Monoamine oxidase (MAO) are favoenzymes that metabolize neurotransmitter, dietary and xenobiotic amines to their corresponding aldehydes with the production of hydrogen peroxide. Two isoforms, MAO-A and MAO-B, are expressed ... -
Investigation Of The Monoamine Oxidase Inhibition Properties Of Benzoxathiolone Derivatives
(Springer, 2023)The treatment of neuropsychiatric and neurodegenerative disorders such as depression and Parkinson’s disease represent significant challenges in healthcare. Enzymes that metabolise neurotransmitter amines are important ... -
Measurement Invariance Of The Meaning In Life Questionnaire Across 17 Countries
(Springer, 2023)The Meaning in Life Questionnaire assesses presence of and search for meaning in life. Although the questionnaire has shown promising psychometric properties in samples from diferent countries, the scale’s measurement ... -
Urinary metabolomics, dietary salt intake and blood pressure: the African-PREDICT study
(Springer Nature, 2023)In Black populations excessive salt intake may exacerbate the genetic predisposition to hypertension and promote the early onset of cardiovascular disease. Ethnic differences in the interaction between sodium intake and ... -
Homiletical-liturgical perspectives on life in the Anthropocene: the preeminence of peoples cognition
(SAGE, 2024)Older black people in South Africa stay a part of an extended family structure well into old age,irrespective of the family’s ability to provide the necessary care. South Africa’s (SA) under-developed infrastructure creates ... -
Differences in calculated body fat percentage estimated from published equations based on bioelectric impedance analysis in healthy young South African adults
(SAGE, 2023)Adult overweight and obesity, in addition to the intake of saturated fat and total serum cholesterol mustbe monitored as biological risk factors for non-communicable diseases (NCDs). Bioelectric impedance analysis (BIA)provides ... -
Self-reported level of cultural competence of midwives in the North-West province of South Africa
(SAGE, 2023)Limited research on cultural competence in nursing, midwifery, and education exists within low- andmiddle-income countries such as South Africa (SA). This study aimed to describe midwives’ self-reported levels of ... -
Effect of fatty acid profiles in varying recipes of ready-to-use therapeutic foods on neurodevelopmental and clinical outcomes of children (6-59 months) with severe wasting ? A systematic review
(OUP, 2023)In 2020, 13.6 million children under 5 years suffered from severe acute malnutrition (SAM)/wasting. Standard ready-to-use therapeutic foods (RUTFs) improve polyunsaturated fatty acid (PUFA) status but contain suboptimal ... -
Flow Cytometry as an analytical method of drug–induced apoptosis in 3D bioprinted melanoma cells
(IOP, 2023)Three-dimensional (3D) cell culture systems have gained increasing interest in drug discovery and tissue engineering due to its inherent advantages in providing more physiologically relevant information and more predictive ... -
Life-threatening, high-intensity trauma- and context-dependent anxiety in zebrafish and its modulation by epinephrine
(Elsevier, 2023)Trauma-related psychopathology transpires in some individuals after exposure to a life-threatening event. While aberrant adrenergic processes may contribute to this, a clear understanding of how said processes influence ... -
Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances
(Elsevier, 2023)Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins and ... -
Quinolone analogues of benzothiazinone: Synthesis, antitubercular structure-activity relationship and ADME profiling
(Elsevier, 2023)Mycobacterium tuberculosis (Mtb) has an impermeable cell wall which gives it an inherent ability to resist many antibiotics. DprE1, an essential enzyme in Mtb cell wall synthesis, has been validated as a target for several ... -
Incidence patterns of childhood cancer in two tertiary hospitals in Ghana from 2015 to 2019: A retrospective observational study
(Elsevier, 2023)Background: Accurate epidemiological data are vital in estimating the burden of disease in a country. Little is known about the incidence of childhood cancer in Ghana. This study describes the incidence patterns of cancer ... -
Striatal adenosine A2A receptor involvement in normal and large nest building deer mice: Perspectives on compulsivity and anxiety
(Elsevier, 2023)Obsessive-compulsive disorder (OCD) is characterized by recurring obsessive thoughts and repetitive behaviors that are often associated with anxiety and perturbations in cortico-striatal signaling. Given the suboptimal ... -
Regulation of long-term care for older persons: a scoping review of empirical research
(Cambridge University Press, 2023)Objective: Not only care professionals are responsible for the quality of care but other stakeholders including regulators also play a role. Over the last decades, countries have increasingly invested in regulation of ...
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