Faculty of Health Sciences
Recent Submissions
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Comparison of body mass index and fat percentage criteria classification of 7-13 year-old rural boys in South Africa
(BMC, 2020)Abstract Background: The aim of this paper was to investigate whether BMI and fat percentage classification criteria, would classify a sample of 7–13 year old boys from a rural background in similar nutritional ... -
Methylene blue analogues: in vitro antimicrobial minimum inhibitory concentrations and in silico pharmacophore modelling
(Elsevier, 2020)It has been shown that methylene blue has antimicrobial properties although few studies have determined its minimum inhibitory concentration (MIC), which is the gold standard used to measure antimicrobial activity. The ... -
Metronidazole-conjugates: a comprehensive review of recent developments towards synthesis and medicinal perspective
(Elsevier, 2020)Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry due to their numerous biological activities. Moreover, many clinical candidates based on this chemical core have been reported to be ... -
COVID-19 across Africa: epidemiologic heterogeneity and necessity of contextually relevant transmission models and intervention strategies
(American College of Physicians, 2020)Coronavirus disease 2019 (COVID-19) has rapidly emerged as a global public health threat with epicenters in regions of China, parts of Europe, and larger urban centers across North America (1). By comparison, population-level ... -
Towards a methodology for online VR application testing
(IEEE, 2020)Performing online testing for applications is a common practice in business, but for research without much control over the participants it is unknown as to what this process should look like and what could be possible ... -
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ... -
Reflections on the OECD guidelines for in vitro skin absorption studies
(Elsevier, 2020)At the 8th conference of Occupational and Environmental Exposure of the Skin to Chemicals (OEESC) (16–18 September 2019) in Dublin, Ireland, several researchers performing skin permeation assays convened to discuss in vitro ... -
2020 International Society of Hypertension global hypertension practice guidelines - lifestyle modification. Reply
(Wolters Kluwer, 2020)The 2020 ISH Global Hypertension Practice Guidelines [1] include a detailed list of lifestyle modifications with varying levels of evidence for the reduction of blood pressure and cardiovascular risk. We listed some novel ... -
Diet and sedentary behaviour in relation to mortality in US adults with a cardiovascular condition: results from the National Health and Nutrition Examination Survey linked to the US mortality registry
(Cambridge Univ Pess, 2020)CVD is the most common chronic condition and the highest cause of mortality in the USA. The aim of the present work was to investigate diet and sedentary behaviour in relation to mortality in US CVD survivors. The National ... -
Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide
(Wiley, 2020)Leishmaniasis is a vector‐borne parasitic disease that mostly affects populations in tropical and subtropical countries. There is currently no vaccine to protect against and only a handful of drugs are available to treat ... -
C3 amino-substituted chalcone derivative with selective adenosine rA1 receptor affinity in the micromolar range
(Springer, 2020)To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15–36 and 37–41) and structurally related ... -
Coexisting conditions among children and adolescents with cancer in a section of the South African private health sector: perspectives from drug utilization data
(Atlantis Press, 2020)Coexisting conditions are relatively common in children with cancer, however, there is a paucity of information on the prevalence of coexisting conditions in children with cancer in South Africa. This cross-sectional study ... -
Family structure and history of childhood trauma: associations with risk-taking behavior among adolescents in Swaziland
(Frontiers Media, 2020)Introduction: Risk-taking and self-harm behavior among adolescent are a global challenge. This study explored family structure and history of childhood trauma and their association with risk-taking and self-harm behaviors ... -
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
(Elsevier, 2020)Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ... -
The use of cytokines and oxidative stress markers as indicators for drug safety
(Elsevier, 2020)Safety and efficacy are of concern in developing new compounds. There is a paucity on the changes made by new compounds on inflammatory cytokines in combination with oxidative stress markers. Cytokines are potential markers ... -
The safety and efficacy of Meriva (R) and ginger extract combination in Pheroid (R) against lung cancer
(Elsevier, 2020)Lung cancer is the leading cause of cancer related deaths, globally, with poor survival profile. Cisplatin is frequently used in the treatment of many solid tumors including lung cancer despite its toxicity; ototoxicity, ... -
Physicochemical stability of enriched phenolic fractions of Cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones
(Thieme, 2020)Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α-glucosidase in vitro. The present study investigated ex vivo ... -
Determinants of plasma fibrin clot lysis measured using three different assays in healthy subject
(Elsevier, 2021)Introduction Several methods for measuring fibrinolytic capacity in plasma have been developed yielding frequently inconsistent results. We investigated which factors determine fibrinolytic capacity in three plasma-based ... -
In silico modelling in the development of novel radiolabelled peptide probes
(Bentham Science, 2020)This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal ... -
Synthesis and in vitro Leishmania promastigote growth inhibition efficacy of novel 4(3H)-quinazolinone derivatives
(ARKAT USA, 2020)Molecular hybridization is an increasingly important strategy in rational drug design and development. A series of novel quinazolinone-triazole hybrids have been synthesized and their antileishmanial activity investigat ...
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