Browsing Faculty of Health Sciences by Author "ade6e2ca-7f8e-44ac-aabc-63ed19248b38"
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Hexacyclododecylamines with Sigma-1 receptor affinity and calcium channel modulating ability
Joubert, Jacques; Greyling, Yolande; Van Dyk, Sandra; Strydom, Natasha; Geldenhuys, Werner J. (Bentham Open, 2019)Introduction: Recent research points to the Sigma Receptor (σR) as a possible neuromodulatory system with multi-functional action and σ1Rs have been suggested as a drug target for a number of CNS conditions. Hexacyclodo ... -
Synthesis and biological evaluation of pentacycloundecylamines and triquinylamines as voltage-gated calcium channel blockers
Young, Lois-May; Domingo, Olwen C.; Malan, Sarel F.; Geldenhuys, Werner J.; Van der Schyf, Cornelis J. (Wiley, 2016)Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as ...