Browsing Faculty of Health Sciences by Subject "Schizophrenia"
Now showing items 1-10 of 13
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The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical n-methyl-d-aspartate and d1 receptor binding in rats
(Elsevier, 2010)Glutamate and dopamine disturbances are implicated in frontal cortical dysfunction in schizophrenia. Little, however, is known about the nature of dopamine D1 and N-methyl-d-aspartate (NMDA) receptor interactions in the ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
(Elsevier, 2011)Social isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR ... -
N-acetyl cysteine reverses social isolation rearing induced changes in cortico-striatal monoamines in rats
(Springer, 2013)Schizophrenia is causally associated with early-life environmental stress, implicating oxidative stress in its pathophysiology. N-acetyl cysteine (NAC), a glutathione precursor and antioxidant, is emerging as a useful ... -
The nature of relapse in schizophrenia
(BioMed Central, 2013)Background: Multiple relapses characterise the course of illness in most patients with schizophrenia, yet the nature of these episodes has not been extensively researched and clinicians may not always be aware of important ... -
Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development
(ACS, 2015)Schizophrenia is a life altering disease with a complex etiology and pathophysiology, and although antipsychotics are valuable in treating the disorder, certain symptoms and/or sufferers remain resistant to treatment. ... -
Neuroprogression in schizophrenia: pathways underpinning clinical staging and therapeutic corollaries
(Sage, 2014)Objective: Whilst dopaminergic dysfunction remains a necessary component involved in the pathogenesis of schizophrenia, our current pharmacological armoury of dopamine antagonists does little to control the negative ... -
A randomized, controlled trial of omega-3 fatty acids plus an antioxidant for relapse prevention after antipsychotic discontinuation in first-episode schizophrenia
(Elsevier, 2014)Background: While antipsychotics are effective in the maintenance treatment of schizophrenia they have safety and tolerability risks. We investigated whether a combination of omega-3 polyunsaturated fatty acids (ω−3 ... -
The schizophrenia and bipolar disorder associated BRD1 gene is regulated upon chronic restraint stress
(Elsevier, 2012)Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone ...