Browsing Faculty of Health Sciences by Title
Now showing items 217-236 of 1841
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C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase
(Thieme, 2017)Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ... -
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study
(Elsevier, 2018)Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ... -
Caffeine as a lead compound for the design of therapeutic agents for the treatment of Parkinson’s disease
(Bentham Science, 2015)The current pharmacological therapies for the treatment of Parkinson’s disease are mostly inadequate and recent, improved therapeutic agents are required. Two important molecular targets for the design of anti-parkinsonian ... -
Caffeine improves triathlon performance: a field study in males and females
(Human Kinetics, 2018)The ergogenic effect of caffeine on endurance exercise is commonly accepted. We aimed to elucidate realistically the effect of caffeine on triathlon event performance using a field study design, while allowing investigation ... -
Can ambulatory blood pressure measurements substitute assessment of subclinical cardiovascular damage?
(Kluwer, 2012)Objective: We have previously demonstrated that markers of subclinical organ damage (SOD) improve cardiovascular risk prediction in healthy individuals. We wanted to investigate whether this additive effect of SOD was due ... -
Cancer patients' ilness expierences during a group intervention
(PSYSSA, 2008) -
Cancer treatment in South Africa: a narrative literature review
(Taylor & Francis, 2012)Due to the advances in cancer treatment, there are a growing number of cancer survivors. Finishing treatment rarely indicates the end of the cancer experience. As a result, cancer management has shifted from an acute care ... -
A canning quality model for small white bean lines selected for breeding (Phaseolus vulgaris L.)
(Forum Press International, 2008) -
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists
(Elsevier, 2016)A novel series of carbamate substituted 2-amino-4,6-diphenylpyrimidines was evaluated as potential dual adenosine A1 and A2A receptor antagonists. The majority of the synthesised compounds exhibited promising dual affinities, ... -
Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound
(Wiley, 2015)A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory ... -
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
(Wiley, 2016)This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ... -
Carbon‐14 radiolabeling and tissue distribution evaluation of MMV390048
(Wiley, 2016)The antimalarial compound MMV390048 ([14C]-11) was labeled with carbon-14 isotope via a 3-step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon-14 labeled methyl iodide with a radiochemical ... -
Cardiac
(Wiley, 2016)This chapter highlights various non-automated classical in vitro techniques used today to evaluate drug effects on cardiac electrophysiology. It then outlines a three-pronged preclinical initiative called the Comprehensive ... -
Cardiac troponin T as early marker of subclinical cardiovascular deterioration in black hypertensive women
(Elsevier, 2017)Background Hypertensive heart disease is a rising concern, especially among black South African women. As high sensitivity cardiac troponin T (cTnT) is a marker of cardiomyocyte damage, we determined the potential link ... -
Cardiac, respiratory and postural influences on venous return of internal jugular and vertebral veins
(Elsevier, 2017)It is known from physiology that heartbeat and respiration influence venous return, but little is known regarding the extent to which these two factors affect flow. In this study, we estimated the prevalence of cardiac- ... -
Cardiometabolic changes in treated versus never treated HIV-infected Black South Africans: the PURE study
(Elsevier, 2014)Background The use of antiretroviral treatment is known to be accompanied by several negative health outcomes and may negatively affect a country such as South Africa, which is the most burdened by the human immunodeficiency ... -
Cardiometabolic markers to identify cardiovascular disease risk in HIV-infected black South Africans
(2014)Background. The prevalence of HIV is the highest in sub-Saharan Africa; South Africa (SA) is one of the most affected countries with the highest number of adults living with HIV infection in the world. Besides ... -
Cardiovascular disease and nutrition: the use of food-based dietary guidelines for prevention in Africa
(South African Heart Association, 2011)There is no doubt that morbidity and mortality from cardiovascular disease (CVD) are increasing in many African countries. Research and implementation of public health nutrition programmes in the developed world have shown ... -
Cardiovascular function and psychological distress in urbanised black South African : The SABPA study
(Clinics cardiv publishing, 2010) -
Cardiovascular function is not associated with creatine kinase activity in a black African population: the SABPA study
(Biomed Central Ltd, 2016)Background: Higher creatine kinase (CK) activity is associated with the development of cardiovascular disease in black African populations. We compared CK activity and investigated associations of blood pressure with CK ...
