Browsing Faculty of Health Sciences by Author "Zeevaart, Jan R."
Now showing items 1-5 of 5
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68Ga-NOTA-functionalized ubiquicidin: cytotoxicity, biodistribution, radiation dosimetry, and first-in-human PET/CT imaging of infections
(Society of Nuclear Medicine and Molecular Imaging, 2018)Ubiquicidin is an antimicrobial peptide with great potential for nuclear imaging of infectious diseases, as its cationic-rich fragment TGRAKRRMQYNRR (UBI) has been functionalized with NOTA to allow complexation to 68Ga ... -
Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound
(Wiley, 2015)A potential anti-TB compound bearing a nitroimidazole moiety from iThemba Pharmaceuticals TB chemical library exhibits promising in vitro activity in the microplate almar blue assay (MABA) with a minimum inhibitory ... -
Carbon-14 radiolabelling and tissue distribution evaluation of a potential anti-TB compound
(Wiley, 2016)This paper describes a five-step synthesis of a carbon-14-labelled pyrazole compound (11). A total of 2.96 MBq of 11 was obtained with the specific activity of 2242.4 MBq/mmol. The radiochemical purity was >99%, and the ... -
Carbon‐14 radiolabeling and tissue distribution evaluation of MMV390048
(Wiley, 2016)The antimalarial compound MMV390048 ([14C]-11) was labeled with carbon-14 isotope via a 3-step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon-14 labeled methyl iodide with a radiochemical ... -
Synthesis, 68Ga-radiolabeling, and preliminary in vivo assessment of a depsipeptide-derived compound as a potential PET/CT infection imaging agent
(Hindawi, 2015)Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An alarming shortage of infection-selective radiopharmaceuticals exists for overcoming the ...
